A review on furan: Formation, analysis, occurrence, carcinogenicity, genotoxicity and reduction methods

Critical Reviews in Food Science and Nutrition
Zahra BatoolLin Li

Abstract

Furan (C4H4O) is a volatile, heterocyclic and carcinogenic heterocyclic chemical compound occurring in a wide range of thermally processed foods. Several studies have been conducted to analyze the formation conditions, triggering furan formation via model systems. Furan can be encountered via various pathways including thermal degradation, oxidation of polyunsaturated fatty acids, thermal rearrangement of carbohydrates in the presence of amino acids, thermal degradation of certain amino acids. Furan has been proven to cause cancer in experimental animal models and classified as a possible human carcinogen by International agency for research on cancer based on sufficient evidences. Thus, different strategies should be developed to reduce furan contents in commercially available food stuffs while food processing. This review summarizes some current evidences of furan formation from different precursors, analytical methods for its detection, and its toxicity that might lead to carcinogenicity and genotoxicity with human risk assessment. In addition, furan occurrence in different thermally processed foods entailed by several recent studies as well as furan mitigation strategies during food processing have also been illustrated in ...Continue Reading

References

Jun 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·T P CameronR E Tarone
Oct 1, 1995·Chemical Research in Toxicology·L J ChenL A Peterson
Sep 24, 2004·Biochemical and Biophysical Research Communications·Tonika BohnertPeter C Dedon
Oct 28, 2004·Journal of Agricultural and Food Chemistry·Carolina Perez Locas, Varoujan A Yaylayan
Mar 21, 2006·Chemical Research in Toxicology·Michael C ByrnsLisa A Peterson
Mar 30, 2006·Journal of Agricultural and Food Chemistry·Julia MärkTilmann Märk
Sep 22, 2007·Food Additives and Contaminants·A LimacherI Blank
Apr 29, 2008·Journal of Agricultural and Food Chemistry·Anita LimacherImre Blank
Jan 2, 2010·Chemical Research in Toxicology·Ding Lu, Lisa A Peterson
May 21, 2010·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·A BecalskiE Vavasour
Dec 4, 2010·Journal of Agricultural and Food Chemistry·Fien Van LanckerNorbert De Kimpe
Jan 14, 2011·Toxicologic Pathology·Bob ThoolenJerrold M Ward
May 30, 2012·Molecular Nutrition & Food Research·Sabrina MoroAngela Mally
Aug 7, 2012·Molecular Nutrition & Food Research·Carolin NeuwirthAngela Mally
Sep 19, 2012·Journal of Agricultural and Food Chemistry·María MariottiFranco Pedreschi
Nov 23, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wu SijiaYuan Yuan
Feb 20, 2014·Journal of Food Science·Robert SevenichDietrich Knorr
Mar 13, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Aline de ContiIgor Petrovych Pogribny
Oct 26, 2014·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Ashley N TerrellLisa A Peterson
Dec 20, 2014·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Stijn PalmersAnn Van Loey
Jul 21, 2015·Food Chemistry·Min Yeop KimKwang-Geun Lee
Sep 15, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M I ChurchwellD R Doerge
Feb 18, 2016·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Stijn PalmersAnn Van Loey
May 5, 2016·Journal of Applied Toxicology : JAT·Daisuke HibiTakashi Umemura
Oct 30, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Aline de ContiIgor P Pogribny
Nov 23, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Linda S Von TungelnFrederick A Beland
Jan 6, 2018·Archives of Toxicology·Ivonne M C M RietjensGerhard Eisenbrand
Feb 8, 2018·Food Chemistry·Concetta CondursoAntonella Verzera
May 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Beate KettlitzRichard H Stadler

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Citations

Dec 30, 2020·Critical Reviews in Food Science and Nutrition·Lipeng HanLi Niu
Sep 30, 2021·Critical Reviews in Food Science and Nutrition·Jingyun ZhengStéphane Bayen

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Methods Mentioned

BETA
transgenic
acetylation
thermal treatment

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