A review on immobilised aptamers for high throughput biomolecular detection and screening

Analytica Chimica Acta
Caleb AcquahClarence M Ongkudon

Abstract

The discovery of Systematic Evolution of Ligands by Exponential Enrichment (SELEX) assay has led to the generation of aptamers from libraries of nucleic acids. Concomitantly, aptamer-target recognition and its potential biomedical applications have become a major research endeavour. Aptamers possess unique properties that make them superior biological receptors to antibodies with a plethora of target molecules. Some specific areas of opportunities explored for aptamer-target interactions include biochemical analysis, cell signalling and targeting, biomolecular purification processes, pathogen detection and, clinical diagnosis and therapy. Most of these potential applications rely on the effective immobilisation of aptamers on support systems to probe target species. Hence, recent research focus is geared towards immobilising aptamers as oligosorbents for biodetection and bioscreening. This article seeks to review advances in immobilised aptameric binding with associated successful milestones and respective limitations. A proposal for high throughput bioscreening using continuous polymeric adsorbents is also presented.

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Citations

Feb 27, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Caleb AcquahClarence M Ongkudon
Jan 19, 2016·Analytical and Bioanalytical Chemistry·Natalia Lopez-BarbosaJohann F Osma
Jan 18, 2016·Molecular Immunology·Roald Nezlin
Mar 17, 2016·Critical Reviews in Analytical Chemistry·Sze Y TanMichael K Danquah
May 29, 2016·Journal of Biotechnology·Samaneh Rasoulinejad, Seyed Latif Mousavi Gargari
Aug 28, 2016·Analytica Chimica Acta·Un-Jung Kim, Byoung Chan Kim
Mar 23, 2017·Nanoscale·Rainer Joachim Schwarz, Clemens Richert
Feb 5, 2019·Critical Reviews in Food Science and Nutrition·Caleb AcquahMichael Kobina Danquah
Jun 8, 2017·Journal of Toxicology·Marzieh JafariBahram Daraei
Jan 26, 2017·Canadian Journal of Microbiology·Hanif AlfavianArvin Medhat
Sep 9, 2017·Analytical and Bioanalytical Chemistry·Dominic AgyeiMichael K Danquah
Aug 9, 2020·Frontiers in Genetics·Eren M Veziroglu, George I Mias
Nov 3, 2020·Biotechnology and Bioengineering·Zahra KhoshbinAsma Verdian
Jan 26, 2021·Cellular and Molecular Bioengineering·Caleb AcquahMichael K Danquah
Feb 26, 2019·Biotechnology Advances·Arabelle CassedyRichard O'Kennedy
Apr 29, 2021·Journal of Electroanalytical Chemistry·G BalkouraniP Tsiakaras
Nov 8, 2019·Analytical Chemistry·Valérie PichonAudrey Combès
Jan 5, 2021·Analytical Chemistry·Vasileia VogiaziDionysios D Dionysiou
Jun 10, 2020·Journal of the American Chemical Society·Kaiming ChenWeihong Tan

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