A Review on the Effect of Tumor Necrosis Factor Inhibitors on Structural Progression in Early Axial Spondyloarthritis Using Magnetic Resonance Imaging

Rheumatology and Therapy
Ko-Jen LiEhab Mahgoub

Abstract

Considering the progressive nature of axial spondyloarthritis (axSpA), it is important to determine whether tumor necrosis factor alpha (TNFα) inhibitors have an effect on early inflammatory and structural lesions detected using magnetic resonance imaging (MRI). A search of MEDLINE/PubMed for full-text, English-language articles on randomized controlled trials (RCTs) of adalimumab, certolizumab, etanercept, golimumab, or infliximab published since January 2007 was conducted in February 2018 and again in December 2018. The collected articles reported on inflammatory or fatty lesion progression in the spine or sacroiliac joint (SIJ), determined using MRI, in a population that included at least 40% of patients with early axSpA, defined as non-radiographic axSpA. Of the 105 articles retrieved, 19 were included in this review, of which the majority were on etanercept (n = 11). A majority of selected articles included information on inflammatory lesions (SIJ 15/19; spine 12/19). All five TNFα inhibitors showed benefits on inflammation, assessed by MRI, in patients with early axSpA for up to 204 weeks of treatment. Structural progression in SIJ and the spine was assessed in 6/19 and 3/19 articles, respectively, with mixed evidence on ...Continue Reading

References

May 16, 2012·Annals of the Rheumatic Diseases·Kay-Geert A HermannUNKNOWN Assessment in SpondyloArthritis international Society (ASAS)
Jun 30, 2016·The New England Journal of Medicine·Joel D TaurogRobert A Colbert
Nov 20, 2016·International Journal of Rheumatic Diseases·James Cheng-Chung WeiLyndon Llamado
Jan 15, 2017·Annals of the Rheumatic Diseases·Désirée van der HeijdeJürgen Braun
Jul 8, 2017·Annals of the Rheumatic Diseases·Maxime DougadosDésirée van der Heijde
Jul 29, 2017·Current Rheumatology Reports·Denis Poddubnyy, Joachim Sieper

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