A Review on the Effects of Bisphenol A and Its Derivatives on Skeletal Health

International Journal of Medical Sciences
Kok-Yong ChinWun Fui Mark-Lee

Abstract

Bisphenol A (BPA) is an endocrine disruptor which can bind to the oestrogen receptor. It also possesses oestrogenic, antiandrogenic, inflammatory and oxidative properties. Since bone responds to changes in sex hormones, inflammatory and oxidative status, BPA exposure could influence bone health in humans. This review aimed to summarize the current evidence on the relationship between BPA and bone health derived from cellular, animal and human studies. Exposure to BPA (0.5-12.5 µM) decreased the proliferation of osteoblast and osteoclast precursor cells and induce their apoptosis. Bisphenol AF (10 nM) enhanced transforming growth factor beta signalling but bisphenol S (10 nM) inhibited Wnt signalling involved in osteoblast differentiation in vitro. In animals, BPA and its derivatives demonstrated distinct effects in different models. In prenatal/postnatal exposure, BPA increased femoral bone mineral content in male rats (at 25 ug/kg/day) but decreased femoral mechanical strength in female mice (at 10 µg/kg/day). In oestrogen deficiency models, BPA improved bone mineral density and microstructures in aromatase knockout mice (at very high dose, 0.1% or 1.0% w/w diet) but decreased trabecular density in ovariectomized rats (at 37 o...Continue Reading

Citations

Mar 9, 2019·Current Molecular Pharmacology·Shirin A Hafezi, Wael M Abdel-Rahman
Sep 11, 2019·Nutrients·Natalia AndújarAnd Ana Rivas
Jan 10, 2021·Food Chemistry·Yuhuan ZhangJianke Li
Feb 24, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Serap Turan
Apr 19, 2021·Ecotoxicology and Environmental Safety·Kristen G HarnettSonya M Schuh
May 1, 2021·International Journal of Molecular Sciences·Li-Hsuan WangKuo-Hu Chen
Sep 24, 2021·Annual Review of Pharmacology and Toxicology·Akhgar GhassabianLeonardo Trasande

❮ Previous
Next ❯

Methods Mentioned

BETA
hormone replacement

Related Concepts

Related Feeds

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
International Journal of Environmental Research and Public Health
Kok-Yong Chin, Soelaiman Ima-Nirwana
© 2022 Meta ULC. All rights reserved