A Review on the Pharmacological Activities and Phytochemicals of Alpinia officinarum (Galangal) Extracts Derived from Bioassay-Guided Fractionation and Isolation

Pharmacognosy Reviews
Aida Maryam BasriNorhayati Ahmad

Abstract

The rhizomes of Alpinia officinarum Hance have been used conventionally for the treatment of various ailments, triggering a wide interest from the scientific research community on this ethnomedicinal plant. This review summarizes the phytochemical and pharmacological properties of the extracts and fractions from A. officinarum, a plant species of the Zingiberaceae family. Different parts of the plant - leaves, roots, rhizomes, and aerial parts - have been extracted in various solvents - methanol, ethanol, ethyl acetate, hexane, dichloromethane, aqueous, chloroform, and petroleum ether, using various techniques - Soxhlet extraction, maceration, ultrasonication, and soaking, whereas fractionation of the plant extracts involves the solvent-solvent partition method. The extracts, fractions, and isolated compounds have been studied for their biological activities - antioxidant, antibacterial, anti-inflammatory, anticancer, antiproliferative, inhibition of enzymes, as well as the inhibition of nitric oxide production. More findings on A. officinarum are certainly important to further develop potential bioactive drug compounds.

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Citations

Mar 21, 2018·Journal of Biomolecular Structure & Dynamics·Yuvaraj Geetha Rani, Baddireddi Subhadra Lakshmi
May 31, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rajendra SangarajuRamakrishna Sistla
Oct 11, 2017·Pharmacognosy Reviews·Hamdollah DelavizNaser Farhadi
Sep 4, 2020·F1000Research·Nurul Ashifah ShafieNorhayati Ahmad
Nov 22, 2019·Anti-cancer Agents in Medicinal Chemistry·Rumana AhmadArvind K Srivastava
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lujain AloumGeorg A Petroianu
Sep 28, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nabil M Abdel-HamidDaniah Muneam Hamid

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Methods Mentioned

BETA
chromosomal aberrations

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