A review on the use of confocal laser endomicroscopy in the bile duct.

Gastroenterology Research and Practice
Ioana SmithMichel Kahaleh

Abstract

Background. Current methods to diagnose malignant biliary strictures are of low sensitivity. Probe-based confocal laser endomicroscopy (pCLE) is a new approach that can be used to evaluate in vivo histopathology of the GI tract. This paper is of studies evidencing pCLE's application in the diagnosis of indeterminate biliary strictures. Methods. This paper examined peer-reviewed studies conducted between January 2000 and November 2011. A PubMed search for relevant articles was performed using the following keywords:"pCLE", "confocal", "endomicroscopy", "probe-based confocal laser endomicroscopy", "and "bile duct". Further individual review was done to assess the screened articles' relevance to the topic. Results. After individual review, 6 studies were included; with a cumulative sample size of 165, with 75 subjects identified as having a malignancy. These studies included tertiary care centers in Germany, France, and USA, including one multicenter trial. 3 studies assessed pCLE's specificity (range 67%-88%) ,sensitivity (range 83%-98), and accuracy (range 81%-86%). Conclusion. Confocal endomicroscopy is a novel and promising modality for the biliary tree. Further studies need to be conducted both to establish its usefulness for...Continue Reading

References

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Citations

Mar 12, 2013·Diagnostic and Therapeutic Endoscopy·Shajan PeterC Mel Wilcox
Dec 17, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Michel KahalehMarc Giovannini
Apr 5, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Cherie-Ann O NathanVikas Mehta
Jun 10, 2014·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Efthymios YpsilantisAmyn Haji
Mar 20, 2013·Current Opinion in Gastroenterology·Sachin Wani, Raj J Shah

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

pCLE

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