A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiaowei CuiChunchao Han

Abstract

Traditional Chinese Medicine (TCM) has been widely used in China and is regarded as the most important therapeutic. Polygonatum sibiricum (PS), a natural plant used in traditional Chinese medicine, has various functions associated with a number of its components. There are many compositions in PS including polysaccharides, steroids, anthraquinone, alkaloids, cardiac glycosides, lignin, vitamins, various acids, and so on. Of these, polysaccharides play a significant role in PS-based therapeutics. This article summarizes Polygonatum sibiricum polysaccharides (PSP) have many pharmacological applications and biological activities, such as their antioxidant activity, anti-aging activity, an anti-fatigue effect, immunity enhancement effect, antibacterial effect, anti-inflammatory effect, hypolipidemic and antiatherosclerotic effects, anti-osteoporosis effect, liver protection, treatment of diabetes mellitus (DM), anti-cancer effect, and may help prevent Alzheimer's disease, and so on. This review summarized the extraction method, purification method, compositions, pharmacological applications, biological activities, biosynthesis, and prospects of PSP, providing a basis for further study of PS and PSP.

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Citations

Nov 7, 2019·Combinatorial Chemistry & High Throughput Screening·Yeqing HuR Zhang
Feb 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ying XieSheng Liu
May 29, 2021·Complementary Therapies in Clinical Practice·Jinlong ZhaoJun Liu
Nov 30, 2021·Journal of Asian Natural Products Research·Yan-Bin RenJin-Hui Wang

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