A revolution for aging research

Biogerontology
M RoseGregory Benford

Abstract

In the year 1992, two publications on age-specific mortality rates revealed a cessation of demographic aging at later ages in very large cohorts of two dipteran species reared under a variety of conditions. Despite some initial concerns about possible artifacts, these findings have now been amply corroborated in the experimental literature. The eventual cessation of aging undermines the credibility of simple Gompertzian aging models based on a protracted acceleration in age-specific mortality during adulthood. The first attempt to explain the apparent cessation of aging was extreme lifelong heterogeneity among groups with respect to frailty. This lifelong heterogeneity theory assumes an underlying Gompertzian aging affecting every member of an adult cohort, with a merely apparent cessation of aging explained in terms of the increasing domination of a slowly aging group among the survivors to late ages. This theory has received several experimental refutations. The second attempt to explain the cessation of aging applied force of natural selection theory. This explanation of the cessation of aging has been corroborated in several Drosophila experiments. In particular, this theory requires that both age-specific survival and age-...Continue Reading

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Citations

Jul 25, 2007·Biogerontology·Anund Hallén
May 1, 2007·Biogerontology·Anund Hallén
Nov 27, 2007·Biology Direct·Michael R Rose, Todd H Oakley
Feb 29, 2008·Journal of Genetics·Predrag ErcegMladen Davidovic
Jan 17, 2009·Journal of Genetics·Michael R RoseLaurence D Mueller
Oct 30, 2012·Experimental Gerontology·Matteo CesariGiovanni Gambassi
Oct 6, 2009·Experimental Gerontology·Laurence D MuellerCasandra L Rauser
Jun 6, 2009·Journal of Theoretical Biology·A Golubev
Jun 13, 2008·Ageing Research Reviews·Piotr Zimniak
Dec 26, 2006·Journal of Theoretical Biology·Mark BebbingtonRicardas Zitikis
Feb 19, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Natalia S Gavrilova, Leonid A Gavrilov
Feb 26, 2016·Biogerontology·Laurence D MuellerMichael R Rose

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