A ribosome-associated inhibitor of in vitro nonsense suppression in [psi-] strains of yeast

FEBS Letters
M F TuiteC S McLaughlin

Abstract

All classes of tRNA-mediated nonsense suppression are much more efficient in yeast cell-free lysates prepared from a [psi+] strain than in those prepared from an isogenic [psi-] strain. Mixed [psi+]/[psi-] lysates do not support efficient suppression. Fractionation of the [psi-] lysate demonstrated the presence of an inhibitor of in vitro suppression that is loosely associated with the 80 S ribosome. The data indicate that the inhibitor is a factor involved in the termination of translation in this simple eukaryote.

References

Sep 1, 1979·Journal of Bacteriology·S W Liebman, F Sherman
Sep 30, 1970·Biochemical and Biophysical Research Communications·M C Ganoza, J K Tomkins
Jul 4, 1970·Nature·A L Beaudet, C T Caskey
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·M F TuiteC S McLaughlin
Nov 22, 1984·Biochimica Et Biophysica Acta·M F Tuite, C S McLaughlin

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Citations

May 1, 1994·Current Genetics·I Stansfield, M F Tuite
May 1, 1994·Molecular Biology Reports·M F Tuite, I Stansfield
Jan 1, 1996·Annual Review of Genetics·R B Wickner
Jan 1, 1997·Annual Review of Genetics·S B Prusiner, M R Scott
Dec 10, 2015·Prion·Mick F TuiteBrian S Cox
Sep 1, 1988·Yeast·B S CoxC S McLaughlin
Dec 1, 1995·Yeast·R B WicknerH K Edskes
Dec 16, 2020·Microorganisms·Anthony BalistreriMatthew Chapman
Dec 10, 1999·Microbiology and Molecular Biology Reviews : MMBR·R B WicknerB T Roberts
Jun 8, 2006·Methods : a Companion to Methods in Enzymology·Mick F Tuite, Brian S Cox
Jul 18, 1997·Science·S V PaushkinM D Ter-Avanesyan

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