A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Hazel PalmerRichard Day

Abstract

To determine the risk: benefit of paracetamol combined with caffeine in the short-term management of acute pain conditions. Database searches were conducted to identify double-blind trials comparing paracetamol/caffeine with paracetamol alone (benefit analysis) and any data pertaining to hepatotoxicity of paracetamol when combined with caffeine (risk analysis). Paracetamol/caffeine (1,000 mg/130 mg) vs paracetamol (1,000 mg) alone. Assessment of benefit has been derived by meta-analysis. Information on the pain condition and number of patients studied, dosing regimen, study design and analgesic outcome measures (total pain relief scores) was extracted and dichotomous outcomes were obtained by calculating the number of patients in each treatment group who achieved at least 50% of the maximum total pain relief score. Assessment of risk has been made by appraisal of the literature. Eight studies from four papers provided sufficient quantitative data for satisfactory meta-analysis. The relative benefit (of achieving at least 50% pain relief) of paracetamol/caffeine vs paracetamol alone was 1.12 (95% Confidence Interval 1.05-1.19) across a number of acute pain states (dysmenorrhoea, headache, post-partum pain, and dental pain). Revi...Continue Reading

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Citations

Jun 5, 2012·Revista brasileira de anestesiologia·Cristiane Tavares, Rioko Kimiko Sakata
Dec 17, 2014·The Cochrane Database of Systematic Reviews·Christopher J DerryR Andrew Moore
Mar 19, 2015·American Journal of Therapeutics·Yulia Treister-Goltzman, Roni Peleg
Jun 21, 2021·Early Human Development·Dimitrios AngelisLina Chalak

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