A RNA sequencing-based six-gene signature for survival prediction in patients with glioblastoma

Scientific Reports
Shuguang ZuoLiping Wang

Abstract

Glioblastoma (GBM) is an aggressive tumor of the central nervous system that has poor prognosis despite extensive therapy. Therefore, it is essential to identify a gene expression-based signature for predicting GBM prognosis. The RNA sequencing data of GBM patients from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases were employed in our study. The univariate and multivariate regression models were utilized to assess the relative contribution of each gene to survival prediction in both cohorts, and the common genes in two cohorts were identified as a final prognostic model. A prognostic risk score was calculated based on the prognostic gene signature. This prognostic signature stratified the patients into the low- and high-risk groups. Multivariate regression and stratification analyses were implemented to determine whether the gene signature was an independent prognostic factor. We identified a 6-gene signature through univariate and multivariate regression models. This prognostic signature stratified the patients into the low- and high-risk groups, implying improved and poor outcomes respectively. Multivariate regression and stratification analyses demonstrated that the predictive value of ...Continue Reading

References

Sep 12, 2001·Neuro-oncology·P Kleihues, H Ohgaki
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Nov 12, 2005·The New England Journal of Medicine·Ingo K MellinghoffPaul S Mischel
Apr 13, 2007·The New England Journal of Medicine·Florence Keime-GuibertUNKNOWN Association of French-Speaking Neuro-Oncologists
Sep 20, 2008·Cancer Gene Therapy·M OlivierP Hainaut
Sep 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sumihito NobusawaHiroko Ohgaki
Mar 4, 2010·Genome Biology·Mark D Robinson, Alicia Oshlack
May 20, 2011·Nature Reviews. Cancer·Lawrence A Loeb
Oct 26, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Albert LaiHeidi S Phillips
Aug 3, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Izaskun ValduviecoFrancesc Graus
Jan 15, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jeong-Heon LeeEun-Hui Jeong
Oct 15, 2013·Cell·Cameron W BrennanUNKNOWN TCGA Research Network
Jun 14, 2014·Science·Anoop P PatelBradley E Bernstein
Jul 7, 2014·Journal of Neuroradiology. Journal De Neuroradiologie·Manal NicolasjilwanUNKNOWN TCGA Glioma Phenotype Research Group
Apr 14, 2015·BioMed Research International·Sebastian López-OchoaFrancisco Arenas-Huertero
Dec 2, 2015·Journal of Cancer Research and Clinical Oncology·Patrapim SunpaweravongSabine Mai
Jan 26, 2016·Aging·Gianluca Bossi
Mar 11, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·P D Delgado-López, E M Corrales-García
Jul 14, 2016·Journal of Neuro-oncology·Lucy GatelyAnthony Dowling
Jun 13, 2017·International Journal of Radiation Oncology, Biology, Physics·Georgia HarrisMichael Back
Jun 18, 2017·Cell·UNKNOWN Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, UNKNOWN Cancer Genome Atlas Research Network
May 29, 2018·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Tomasz Tykocki, Mohamed Eltayeb

❮ Previous
Next ❯

Citations

May 16, 2020·British Journal of Haematology·Mohamad Zamani-AhmadmahmudiFatemeh Soltaninezhad
May 1, 2021·Journal of Personalized Medicine·Vianney GilardSoumeya Bekri
Aug 17, 2021·Journal of Oncology·Xisong LiangZhixiong Liu
Sep 21, 2021·Frontiers in Molecular Biosciences·Shengchao XuQuan Cheng
Dec 31, 2021·Journal of Biochemical and Molecular Toxicology·Yu-Ye XueGuang Cheng

❮ Previous
Next ❯

Datasets Mentioned

BETA
SRP027383
SRP091303

Methods Mentioned

BETA
surgical resection
RNAseq
RNA-seq

Software Mentioned

edgeR
Fastq
hisat2
Bioconductor
htseq
dump app

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.