A robust discriminative multi-atlas label fusion method for hippocampus segmentation from MR image.

Computer Methods and Programs in Biomedicine
Wenna WangYanning Zhang

Abstract

Accurate and automatic segmentation of the hippocampus plays a vital role in the diagnosis and treatment of nervous system diseases. However, due to the anatomical variability of different subjects, the registered atlas images are not always perfectly aligned with the target image. This makes the segmentation of the hippocampus still face great challenges. In this paper, we propose a robust discriminative label fusion method under the multi-atlas framework. It is a patch embedding label fusion method based on conditional random field (CRF) model that integrates the metric learning and the graph cuts by an integrated formulation. Unlike most current label fusion methods with fixed (non-learning) distance metrics, a novel distance metric learning is presented to enhance discriminative observation and embed it into the unary potential function. In particular, Bayesian inference is utilized to extend a classic distance metric learning, in which large margin constraints are instead of pairwise constraints to obtain a more robust distance metric. And the pairwise homogeneity is fully considered in the spatial prior term based on classification labels and voxel intensity. The resulting integrated formulation is globally minimized by t...Continue Reading

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