A robust sliding mode controller with internal model for closed-loop artificial pancreas.

Medical & Biological Engineering & Computing
Amjad Abu-RmilehDarine Zambrano

Abstract

The study presents a robust closed-loop sliding mode controller with internal model for blood glucose control in type-1 diabetes. Type-1 diabetic patients depend on external insulin delivery to keep their blood glucose within near-normal ranges. Closed-loop artificial pancreas is developed to help avoid dangerous, potentially life-threatening hypoglycemia, as well as to prevent complication-inducing hyperglycemia. The proposed controller is designed using a combination of sliding mode and internal model control techniques. To enhance postprandial performance, a feedforward controller is added to inject insulin bolus. Simulation studies have been performed to test the controller, which revealed that the proposed control strategy is able to control the blood glucose well within the safe limits in the presence of meals and measurements errors. The controller shows acceptable robustness against changes in insulin sensitivity, model-patient mismatch, and errors in estimating meal's contents.

References

Apr 6, 2002·American Journal of Physiology. Endocrinology and Metabolism·Roman HovorkaRichard H Jones
Jan 27, 2004·Advanced Drug Delivery Reviews·G M SteilK Rebrin
Sep 24, 2004·Physiological Measurement·Roman HovorkaMalgorzata E Wilinska
Jun 16, 2005·Diabetes Research and Clinical Practice·Gary Scheiner, Bret A Boyer
Aug 26, 2006·Medical & Biological Engineering & Computing·Pier Giorgio FabiettiEugenio Sarti
Aug 29, 2006·Medical & Biological Engineering & Computing·M YamaguchiM Kobayashi
Oct 27, 2006·Diabetes Care·Boris P KovatchevWilliam Clarke
Dec 13, 2006·IEEE Transactions on Bio-medical Engineering·Chiara Dalla ManClaudio Cobelli
Jan 24, 2007·ISA Transactions·Oscar CamachoWinston García-Gabín
Oct 12, 2007·IEEE Transactions on Bio-medical Engineering·Chiara Dalla ManClaudio Cobelli
Aug 19, 2008·Journal of Process Control·Cesar C PalermFrancis J Doyle
Feb 5, 2009·Journal of Process Control·Gianni MarchettiDale E Seborg
Feb 14, 2009·Medical & Biological Engineering & Computing·Pinky DuaEfstratios N Pistikopoulos
Sep 15, 2009·Journal of Diabetes Science and Technology·Marc Breton, Boris Kovatchev
Mar 1, 2007·Journal of Diabetes Science and Technology·Firas H El-KhatibEdward R Damiano
May 1, 2010·Computer Methods and Programs in Biomedicine·Amjad Abu-Rmileh, Winston Garcia-Gabin

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Citations

Jun 23, 2012·Medical & Biological Engineering & Computing·Mattia ZanonClaudio Cobelli
May 9, 2012·Computer Methods and Programs in Biomedicine·Amjad Abu-Rmileh, Winston Garcia-Gabin
Nov 29, 2014·Medical & Biological Engineering & Computing·Giordano LanzolaRiccardo Bellazzi
Mar 17, 2015·Medical & Biological Engineering & Computing·Eleni I GeorgaDimitrios I Fotiadis
Feb 23, 2013·IEEE Transactions on Bio-medical Engineering·A RevertJ Bondia
May 9, 2016·Medical & Biological Engineering & Computing·Fernando García-GarcíaM Elena Hernando
Feb 27, 2013·Journal of Diabetes Science and Technology·Winston Garcia-Gabin, Elling W Jacobsen
Dec 7, 2010·Journal of Diabetes Science and Technology·Solomon S SteinerRoderike Pohl

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