Nov 15, 2014

A robust statistical framework for reconstructing genomes from metagenomic data

BioRxiv : the Preprint Server for Biology
Dongwan Don KangZhong Wang

Abstract

We present software that reconstructs genomes from shotgun metagenomic sequences using a reference-independent approach. This method permits the identification of OTUs in large complex communities where many species are unknown. Binning reduces the complexity of a metagenomic dataset enabling many downstream analyses previously unavailable. In this study we developed MetaBAT, a robust statistical framework that integrates probabilistic distances of genome abundance with sequence composition for automatic binning. Applying MetaBAT to a human gut microbiome dataset identified 173 highly specific genomes bins including many representing previously unidentified species.

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Mentioned in this Paper

Computer Software
Study
Genome
Microbiome
Shotgun protein, Drosophila
Downstream
Species
Analysis
Otu protein, Drosophila
Silo (Dataset)

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