A rodent model of emergency cardiopulmonary bypass resuscitation with different temperatures after asphyxial cardiac arrest.

Resuscitation
Fei HanLance B Becker

Abstract

The use of emergency cardiopulmonary bypass (ECPB) resuscitation after cardiac arrest may offer hope for survival when standard ACLS therapies fail. However, whether cooling adds benefit to ECPB is unknown and we lack an ECPB rodent model for experimental studies. We sought to (a) develop a 72 h survival rodent model using ECPB to treat asphyxial cardiac arrest and (b) use this new model to evaluate early mild and moderate hypothermia versus normothermia during ECPB resuscitation. After 8 min of normothermic asphyxia, three groups of rats were resuscitated with ECPB at 37 degrees C (NORM), 34 degrees C (MILD) and 30 degrees C (MOD) for 1h (n=10 each). During the second resuscitation hour, ECPB was discontinued, ventilatory support was provided and body temperatures were maintained at 37 degrees C for NORM, 34 degrees C for MILD, and from 30 degrees C gradually up to 34 degrees C in 1h for MOD animals. From hours 3 to 8, body temperature was maintained at 37 degrees C for NORM and 34 degrees C for MILD and MOD animals. All rats were initially resuscitated by ECPB. After 72 h, neurological outcome and survival in the MILD (60% survival) and MOD (80%) groups were significantly better than in the NORM (0%) group (p<0.05). Overall p...Continue Reading

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Citations

Sep 22, 2010·Annual Review of Medicine·Joshua W Lampe, Lance B Becker
Mar 22, 2012·Critical Care Clinics·David F GaieskiLance B Becker
Aug 30, 2011·Resuscitation·Michael Christopher Kurz
Jan 4, 2015·The Journal of Surgical Research·Koichiro ShinozakiLance B Becker
Nov 24, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Junhwan KimLance B Becker
Oct 14, 2017·Clinical and Experimental Emergency Medicine·Jung Hoon LeeHyun-Jin Tae
Jul 1, 2018·Journal of the American Heart Association·Koichiro ShinozakiJoshua W Lampe
Jul 23, 2021·Nature Reviews. Neuroscience·Stefano G DanieleNenad Sestan

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