A role for a new vascular enzyme in the metabolism of xenobiotic amines

Circulation Research
P J BoorR Sanduja

Abstract

Although it has long been thought that environmental toxins may play an underlying role in vascular diseases such as atherosclerosis, this concept is not supported by any clear-cut experimental evidence of toxic metabolism by cardiovascular enzymes. In this study, we demonstrate that allylamine, a selective cardiovascular toxin in vivo, is actively metabolized in vitro by a purified vascular enzyme (semicarbazide-sensitive amine oxidase), which has been localized recently to vascular smooth muscle cells. Oxidative deamination of allylamine to a highly toxic aldehyde, acrolein, was blocked through enzyme inhibition by semicarbazide-sensitive amine oxidase suggests that this vascular enzyme's physiological role may include metabolism of exogenous amines.

References

Sep 30, 1979·Toxicology and Applied Pharmacology·P J BoorE S Reynolds
Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M R JuchauE P Benditt
Jun 1, 1987·Journal of Cardiovascular Pharmacology·R M Hysmith, P J Boor
Aug 1, 1988·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·R M Hysmith, P J Boor
Sep 1, 1985·The Journal of Pharmacy and Pharmacology·G A Lyles, I Singh
May 1, 1987·Toxicology·P J Boor, R M Hysmith
Aug 1, 1974·Experimental and Molecular Pathology·J J Lalich, W C Paik
Sep 1, 1981·The Journal of Pharmacy and Pharmacology·R Lewinsohn
Feb 15, 1982·Biochemical Pharmacology·T J Nelson, P J Boor

❮ Previous
Next ❯

Citations

Jan 31, 1995·Biochemical Pharmacology·G A Lyles, J Chalmers
Apr 17, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·J van Dijk, F Boomsma
Oct 26, 2000·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·F BoomsmaA H van den Meiracker
Aug 3, 2001·The EMBO Journal·S Jalkanen, M Salmi
Apr 22, 2003·In Vitro Cellular & Developmental Biology. Animal·M B TrentP J Boor
Jan 1, 2005·Toxicology Mechanisms and Methods·Gundu H R Rao
Jul 25, 2006·Expert Opinion on Drug Metabolism & Toxicology·Bin Gong, Paul J Boor
Mar 14, 1998·Toxicology and Applied Pharmacology·D J Conklin, P J Boor
Mar 18, 1999·Toxicology and Applied Pharmacology·S D LangfordP J Boor
Sep 7, 2001·Toxicology and Applied Pharmacology·D J ConklinP J Boor
Nov 1, 2013·American Journal of Physiology. Renal Physiology·May Y W WongMuh Geot Wong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.