A role for adenosine A2 receptors in the induction of long-term potentiation in the CA1 region of rat hippocampus

Brain Research
K KesseyD J Mogul

Abstract

Although reductions in neurotransmission have been reported in response to agonist-mediated adenosine A1 receptor activation, the implications of A2 receptor activation on synaptic transmission have not been well explored. We examined the role adenosine A2 receptors play in the efficacy of neurotransmission between the Schaffer collateral-CA1 pathway in the rat transverse hippocampal slice. A2 receptor blockade in the presence of complete A1 receptor inhibition led to a reversible reduction of the field excitatory post-synaptic potential (EPSP) slope in response to low-frequency test pulses (0.033 Hz) indicating that A2 receptors can enhance synaptic transmission. A2 receptor blockade by the A2 antagonist, DMPX (3,7-dimethyl-1-propargylxanthine) prevented the induction of tetanus-induced long-term potentiation (LTP) of the EPSP. In contrast, no such effect on LTP induction was observed during A1 receptor blockade. We also examined the effects of DMPX on the induction of LTP during continued A1 receptor blockade with CPT. Under this condition, LTP was significantly reduced when compared to LTP induced in the presence of CPT alone. A similar result was found using the highly polar A2 antagonist 8-SPT (8-(p-sulfophenyl)theophyllin...Continue Reading

References

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Citations

Feb 13, 1999·European Journal of Pharmacology·D K Von Lubitz
Jun 4, 1999·European Journal of Pharmacology·D K von Lubitz
Sep 29, 1999·Progress in Neurobiology·P SvenningssonB B Fredholm
Jun 17, 2003·Journal of Neurochemistry·Susanna RosiGary L Wenk
Mar 8, 2006·Experimental Neurology·Jian Hong WangMaarten van den Buuse
Apr 3, 2001·Expert Opinion on Investigational Drugs·D K von Lubitz
Jul 15, 1999·Nature Neuroscience·J R Sanes, J W Lichtman
Jan 10, 2008·Chemical Reviews·Pier Giovanni BaraldiPier Andrea Borea

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