PMID: 8590556Nov 1, 1995Paper

A role for adenosine in coronary vasoregulation in man. Effects of theophylline and enprofylline

Clinical Physiology
A EdlundA Sollevi

Abstract

Adenosine has been suggested to have a role in regulation of the tone of the cardiac resistance vessels. To elucidate the coronary vasoregulatory role of endogenous adenosine in man, we studied the effects of adenosine receptor antagonism by theophylline on coronary blood flow at rest and during light exercise. However, theophylline may also exert pharmacological effects not related to adenosine antagonism. To clarify the contribution of endogenous adenosine in coronary hyperaemia, the effect of theophylline was compared to that of enprofylline, a xanthine which exerts similar pharmacological effects as theophylline while lacking antagonistic action at adenosine receptors. Twenty healthy subjects (10 males) aged 22-39 years were examined. Coronary sinus (CS) blood flow and blood oxygen content were determined at rest and during supine bicycle exercise, at a load of 50 watts, for 10 min. Thereafter, stepwise infusion of adenosine (30 to 60 micrograms/kg/min into the subclavian vein) was performed. Theophylline or enprofylline treatment was instituted randomly and double-blind (10 in each group), and the procedures (i.e. determinations at rest, during exercise and during infusion of adenosine) were repeated. In all 20 subjects, b...Continue Reading

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Citations

Sep 29, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Maryam Sharifi SanjaniS Jamal Mustafa
Jan 5, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Masanori OhtaHiroto Miura
Nov 1, 2011·Journal of Molecular and Cellular Cardiology·Dirk J DunckerDaphne Merkus
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Apr 18, 2008·The Journal of Pharmacy and Pharmacology·Lucyna Korzycka, Dorota Górska
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Dec 3, 2014·Progress in Cardiovascular Diseases·Rebecca S Bruning, Michael Sturek
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Jan 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·J D TuneE O Feigl
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Mar 24, 2021·Basic Research in Cardiology·Ying ZhangZhichao Zhou

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