A role for alpha-adrenergic receptors in abnormal insulin secretion in diabetes mellitus

The Journal of Clinical Investigation
R P RobertsonD Porte


To determine whether endogenous alpha-adrenergic activity contributes to abnormal insulin secretion in nonketotic, hyperglycemic, diabetic patients, alpha-adrenergic blockade was produced in normal and diabetic subjects. The diabetics had a significantly (P less than 0.01) greater increase in circulating insulin 1 h after an intravenous phentolamine infusion than did the normal subjects. During the phentolamine infusion, there was also a significant augmentation of acute insulin responses to intravenous glucose (20 g) pulses in normal subjects (P less than 0.05) and diabetics (P less than 0.02); this augmentation was fivefold greater in the diabetics. Simultaneous treatment with the beta-adrenergic blocking agent, propranolol, did not alter these findings. Thus a role for exaggerated endogenous alpha-adrenergic activity in abnormal insulin secretion of the diabetic subjects is suggested. To determine whether this alpha-adrenergic activity might be related to elevated circulating catecholamines, total plasma-catecholamine levels were compared in normal and nonketotic diabetic subjects given intravenous glucose pulses. These levels were significantly greater (P less than 0.02) in the diabetic compared to the normal group before t...Continue Reading


Mar 1, 1970·Metabolism: Clinical and Experimental·M G BuseJ Buse
Aug 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R P Robertson, D Porte
Apr 1, 1973·The Journal of Clinical Investigation·R P Robertson, D Porte
Nov 1, 1973·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Linde, T Deckert
Sep 1, 1971·The Journal of Clinical Endocrinology and Metabolism·R L Lerner, D Porte
Jan 1, 1967·The Journal of Clinical Investigation·D Porte

❮ Previous
Next ❯


Mar 1, 1992·Journal of Cellular Biochemistry·R P Robertson
Apr 1, 1979·Diabetologia·N J Christensen
Jun 1, 1982·Klinische Wochenschrift·C Beretta-Piccoli, P Weidmann
Apr 1, 1984·Acta diabetologica latina·M CignarelliR Giorgino
Jan 1, 1979·Irish Journal of Medical Science·J B FerrissD J O'Sullivan
Dec 8, 1998·European Journal of Drug Metabolism and Pharmacokinetics·M A Abd ElazizA Tekle
Oct 29, 1991·European Journal of Pharmacology·S L ChanN G Morgan
Mar 11, 1994·European Journal of Pharmacology·J C JonasJ C Henquin
Apr 1, 1981·Pharmacology, Biochemistry, and Behavior·B E LevinA C Sullivan
Apr 1, 1980·Prostaglandins and Medicine·S A MetzR P Robertson
Mar 1, 2005·Metabolism: Clinical and Experimental·Werner KernBernd Schultes
Apr 18, 1997·European Journal of Pharmacology·D BerdeuG Bertrand
Dec 27, 1979·The New England Journal of Medicine·R P Robertson, S A Metz
Jan 5, 2011·Diabetes, Obesity & Metabolism·I W GallenA Lumb
Sep 1, 1990·British Journal of Pharmacology·T D Plant, J C Henquin
Sep 1, 1977·The Journal of Clinical Investigation·R P Robertson, M Chen
Jun 21, 2014·Experimental & Molecular Medicine·Michelle E KimplePatrick J Casey
Oct 10, 2014·Science Translational Medicine·Yunzhao TangAnders H Rosengren
Jul 1, 1986·The American Journal of the Medical Sciences·M B Davidson
Jul 2, 2015·Basic & Clinical Pharmacology & Toxicology·Suvi T RuohonenTomi Streng
Sep 30, 2016·International Journal of Endocrinology and Metabolism·William B Horton, Jose S Subauste
Feb 18, 2016·Expert Opinion on Investigational Drugs·André J Scheen
Mar 23, 2011·Basic & Clinical Pharmacology & Toxicology·Veronica FagerholmMika Scheinin
Mar 1, 1981·The American Journal of Medicine·M A PfeiferD Porte

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.