A role for an inhibitory connexin in testis?

Developmental Biology
M ChangG Dahl

Abstract

Functional expression of gap junction proteins can be obtained conveniently with the paired oocyte cell--cell channel assay. So far all gap junction proteins (connexins), with the exception of one, have been found to make functional channels either by themselves or as hybrid channels (two hemichannels of different connexin composition). Connexin33 (cx33) appears not to follow this rule. Expression of cx33 in oocytes does not yield functional channels, and attempts to identify another connexin with which cx33 can form hybrid channels have failed so far. The observation was made that cx33 inhibits functional expression of other connexins in a connexin-specific way. While expression of cx32 remains unaffected by coinjection into oocytes of cx33 mRNA together with cx32 mRNA, junctional conductance obtained with cx43 is marginally reduced whereas coinjection of cx33 mRNA at equimolar concentrations almost completely abolishes functional cx37 expression. The fact that testis is the only tissue found to express significant levels of cx33 mRNA together with cx37 and cx43 suggests a possible functional role for an inhibitory connexin. A model is proposed where cx33 limits a cell's capability to make functional channels by allowing forma...Continue Reading

Citations

Sep 25, 1999·Journal of Cellular Physiology·S S ChungC Y Cheng
Aug 15, 2002·Neurochemistry International·M M Fróes, J R L Menezes
Apr 21, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Georges PointisDominique Segretain
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Constantine P FirmeMichael W Baker
Jan 19, 2016·Seminars in Cell & Developmental Biology·Gerald M Kidder, Daniel G Cyr
Aug 1, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Catheleyne D'hondtBernard Himpens
Nov 1, 2007·Journal of Neuroscience Research·Meejin AhnSteven S Scherer
Nov 2, 2005·Biochimica Et Biophysica Acta·Georges PointisDominique Segretain
Aug 2, 2005·Trends in Endocrinology and Metabolism : TEM·Georges Pointis, Dominique Segretain
Jun 1, 2005·Biochimica Et Biophysica Acta·Pauline Phelan
Nov 3, 2011·Biochimica Et Biophysica Acta·Peter BednerMartin Theis
May 23, 2014·Frontiers in Physiology·Shanthini MylvaganamPeter L Carlen
Feb 9, 2017·Canadian Journal of Physiology and Pharmacology·Abdelaziz M HusseinEl-Hussainy M A El-Hussainy
Jan 22, 2015·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Seunghoon Oh
Oct 21, 2005·American Journal of Physiology. Cell Physiology·Celine FioriniGeorges Pointis
Apr 30, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R-Marc PelletierMaría Leiza Vitale
Aug 13, 1998·Glia·R Dermietzel, D C Spray
Mar 22, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Norah DefamieGeorges Pointis
Feb 1, 2002·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Kevin Strange
Aug 12, 2016·Developmental Neurobiology·Michael W Baker, Eduardo R Macagno
Apr 7, 2000·Brain Research. Brain Research Reviews·C K AbramsT A Bargiello

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