PMID: 8959751Jan 1, 1996Paper

A role for B1 and B2 kinin receptors in the modulation of T-kininogen during the acute phase response of inflammation

Peptides
P RaymondA Adam

Abstract

Kinin antagonists at B1 and B2 receptors were examined on liver and serum concentrations of immunoreactive T-kininogen and its gene expression in a rat model of carrageenan-induced hindpaw edema. Whereas the B2 antagonist, HOE140, dose-dependently inhibited the paw edema induced by intraplantar injection of carrageenan, the B1 receptor agonist [Sar(D-Phe8)des-Arg9]BK and antagonist [Lys(Leu8)des-Arg9]BK were ineffective. On its own, HOE140 (3.25 x 10(-7) mol/ paw, intraplantar) had no effect on liver and serum T-kininogen levels but it significantly enhanced liver T-kininogen concentrations in rats pretreated with carrageenan at 8 and 24 h postinjection. In the liver, the most pronounced effect was seen at 24 h (treated 248 +/- 7 micrograms/g vs. untreated 113 +/- 9 micrograms/g). The same dose of HOE140 increased serum T-kininogen from 1255 +/- 57 to 1696 +/- 83 micrograms/ml at 24 h. HOE140 did not affect tissue albumin content during the same period. Transcript measurements revealed that the steady-state level of liver T2-kininogen mRNA was specifically increased by HOE140 during inflammation. In carrageenan-treated rats, the B1 antagonist [Lys(Leu8)des-Arg9]BK also significantly increased liver T-kininogen at 24 h. The pres...Continue Reading

References

Aug 1, 1975·The Journal of Pharmacy and Pharmacology·J M Hall, C Hallett
Aug 1, 1977·Canadian Journal of Physiology and Pharmacology·D RegoliW K Park
Mar 1, 1991·British Journal of Pharmacology·F J HockJ Knolle
Mar 1, 1991·British Journal of Pharmacology·K WirthJ Knolle
Oct 1, 1992·British Journal of Pharmacology·T Griesbacher, F Lembeck
Jan 28, 1992·European Journal of Pharmacology·J Damas, G Remacle-Volon
Apr 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R D CurranT R Billiar
Feb 1, 1991·British Journal of Pharmacology·F LembeckJ Knolle
Aug 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·R M Burch, C DeHaas
Feb 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H Baumann
Jan 1, 1989·Annals of the New York Academy of Sciences·G SchreiberJ Milland
Feb 1, 1989·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·A AdamV Bourdon
Oct 1, 1983·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·B G Blijenberg, B Leijnse
Apr 29, 1983·Biochemical and Biophysical Research Communications·H Okamoto, L M Greenbaum
Jan 1, 1983·Methods in Enzymology·G L Peterson
Jun 1, 1995·Immunopharmacology·F Marceau
Mar 1, 1994·Agents and Actions·E DrelonP Netter
Nov 1, 1993·British Journal of Pharmacology·S H FerreiraS Poole
Sep 1, 1993·The American Review of Respiratory Disease·K J WirthB A Schölkens

❮ Previous
Next ❯

Citations

Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 26, 2009·Advances in Medical Sciences·B Rostkowska-NadolskaU Mazurek
Dec 26, 2007·The Journal of Allergy and Clinical Immunology·Christian DrouetAlbert Adam
Sep 6, 2005·Mechanisms of Ageing and Development·Claudio Acuña-CastilloFelipe Sierra
Feb 15, 2001·Biochemical Pharmacology·P SchaefferJ M Herbert

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.