PMID: 2497454Jan 1, 1989Paper

A role for calcium in gonadotrophin-releasing hormone (GnRH) stimulated secretion of chorionic gonadotrophin by first trimester human placental minces in vitro

Placenta
N Mathialagan, A J Rao

Abstract

In vitro studies using first-trimester human placental minces have shown that stimulation of human chorionic gonadotrophin (hCG) secretion by gonadotrophin-releasing hormone (GnRH) is dependent upon the presence of extracellular calcium. Addition of GnRH to first-trimester placental minces in vitro was found to stimulate 45Ca2+ uptake into placental minces, and the process was associated with an increase in immunoreactive hCG in the medium. Addition of GnRH to placental minces preloaded with 45Ca2+ stimulated the efflux of 45Ca2+ within one minute. The calmodulin inhibitors chlorpromazine and trifluoperazine inhibited the basal uptake and efflux of 45Ca2+, suggesting the involvement of calmodulin in the mobilization of calcium in the placenta.

References

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Citations

Oct 15, 1998·Journal of Molecular Neuroscience : MN·B CemerikicM S Ahmed
May 27, 2003·The Journal of Physiology·L H ClarsonT Powell
Jan 1, 1991·Annals of the New York Academy of Sciences·T Chard
Dec 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·A SzilágyiW G Rossmanith
Mar 1, 1991·Placenta·T M Siler-KhodrG S Khodr

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