A role for CD44 in the production of IFN-gamma and immunopathology during infection with Toxoplasma gondii

The Journal of Immunology : Official Journal of the American Association of Immunologists
S L BlassChristopher A Hunter

Abstract

The interaction of activated CD44 with its ligand, low m.w. hyaluronan, is involved in inflammation, but no role has been identified for this interaction in the regulation of an immune response to infection. In these studies, infection of C57BL/6 mice with Toxoplasma gondii resulted in increased expression of CD44 on T cells, B cells, NK cells, and macrophages, and a small percentage of CD4(+) T cells express an activated form of CD44. Administration of anti-CD44 to infected mice prevented the development of a CD4(+) T cell-dependent, infection-induced inflammatory response in the small intestine characterized by the overproduction of IFN-gamma. The protective effect of anti-CD44 treatment was associated with reduced production of IFN-gamma, but not IL-12, in vivo and in vitro. Furthermore, the addition of low m.w. hyaluronan to cultures of splenocytes or purified CD4(+) T cells from infected mice resulted in the production of high levels of IFN-gamma, which was dependent on IL-12 and TCR stimulation. Together, these results identify a novel role for CD44 in the regulation of IFN-gamma production by CD4(+) T cells during infection and demonstrate a role for CD44 in the regulation of infection-induced immune pathology.

References

Oct 1, 1992·European Journal of Immunology·J Lesley, R Hyman
Jul 1, 1990·The Journal of Experimental Medicine·K MiyakeP W Kincade
Nov 1, 1985·Annals of the Rheumatic Diseases·J D McNeilL G Cleland
Jan 1, 1993·Advances in Immunology·J LesleyP W Kincade
Feb 2, 1996·The Journal of Biological Chemistry·T E TaherS T Pals
May 1, 1996·The Journal of Experimental Medicine·P W NobleH S Shin
Sep 1, 1996·The Journal of Experimental Medicine·Y GuoY Liu
Jun 25, 1998·Current Opinion in Immunology·H OkamuraK Nakanishi
Aug 11, 1999·Journal of Autoimmunity·S NedvetzkiD Naor
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A NobleD M Kemeny
Nov 9, 2000·European Journal of Immunology·N FögerM Zöller

❮ Previous
Next ❯

Citations

Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Franck J D MennechetDominique Buzoni-Gatel
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric N VillegasChristopher A Hunter
Jun 11, 2003·The Journal of Cell Biology·Joanna Cichy, Ellen Puré
Jun 24, 2003·Infection and Immunity·Emma ErikssonMartin E Rottenberg
May 22, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sarah L SagueChristopher A Hunter
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edit I BuzásTibor T Glant
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kasper M A RouschopSandrine Florquin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Jorge CaamañoChristopher A Hunter
The Journal of Immunology : Official Journal of the American Association of Immunologists
Jonathan S SilverChristopher A Hunter
© 2021 Meta ULC. All rights reserved