A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study.

BMC Medical Genetics
Folkert W AsselbergsWiek H van Gilst

Abstract

Studies investigating the genetic and environmental characteristics of atrial fibrillation (AF) may provide new insights in the complex development of AF. We aimed to investigate the association between several environmental factors and loci of candidate genes, which might be related to the presence of AF. A nested case-control study within the PREVEND cohort was conducted. Standard 12 lead electrocardiograms were recorded and AF was defined according to Minnesota codes. For every case, an age and gender matched control was selected from the same population (n = 194). In addition to logistic regression analyses, the multifactor-dimensionality reduction (MDR) method and interaction entropy graphs were used for the evaluation of gene-gene and gene-environment interactions. Polymorphisms in genes from the Renin-angiotensin, Bradykinin and CETP systems were included. Subjects with AF had a higher prevalence of electrocardiographic left ventricular hypertrophy, ischemic heart disease, hypertension, renal dysfunction, elevated levels of C-reactive protein (CRP) and increased urinary albumin excretion as compared to controls. The polymorphisms of the Renin-angiotensin system and Bradykinin gene did not show a significant association w...Continue Reading

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Citations

Jun 1, 2008·Journal of Cardiovascular Translational Research·Marco V PerezEuan A Ashley
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Methods Mentioned

BETA
PCR
Profiler

Software Mentioned

MEANS ( Modular ECG Analysis System )
SPSS
Primer3
MDR
Orange
Genetic Profiler

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