A role for chloride transport in lysosomal protein degradation

Autophagy
Lena Wartosch, Tobias Stauber

Abstract

Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs.

Citations

Aug 8, 2013·Nature Medicine·Ralph A Nixon
Jan 11, 2013·Metallomics : Integrated Biometal Science·Thomas D Lockwood
Aug 25, 2015·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ruchira SinghDavid M Gamm
Jul 26, 2017·ELife·Kasturi ChakrabortyYamuna Krishnan
Mar 5, 2021·Autophagy·Ruoxi ZhangDaolin Tang
Mar 13, 2021·Frontiers in Cell and Developmental Biology·Shroddha BoseTobias Stauber
Apr 28, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Uta RösslerUwe Kornak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Aging: Inhibitors

The feed focuses on the role of nuclear export inhibitors and their effect on autophagy and the aging process.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms