PMID: 11331522May 2, 2001Paper

A role for cingulate pioneering axons in the development of the corpus callosum

The Journal of Comparative Neurology
B G Rash, Linda J Richards

Abstract

In many vertebrate and invertebrate systems, pioneering axons play a crucial role in establishing large axon tracts. Previous studies have addressed whether the first axons to cross the midline to from the corpus callosum arise from neurons in either the cingulate cortex (Koester and O'Leary [1994] J. Neurosci. 11:6608-6620) or the rostrolateral neocortex (Ozaki and Wahlsten [1998] J. Comp. Neurol. 400:197-206). However, these studies have not provided a consensus on which populations pioneer the corpus callosum. We have found that neurons within the cingulate cortex project axons that cross the midline and enter the contralateral hemisphere at E15.5. By using different carbocyanine dyes injected into either the cingulate cortex or the neocortex of the same brain, we found that cingulate axons crossed the midline before neocortical axons and projected into the contralateral cortex. Furthermore, the first neocortical axons to reach the midline crossed within the tract formed by these cingulate callosal axons, and appeared to fasciculate with them as they crossed the midline. These data indicate that axons from the cingulate cortex might pioneer a pathway for later arriving neocortical axons that form the corpus callosum. We also...Continue Reading

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Citations

Feb 1, 2013·Brain : a Journal of Neurology·Gregor KasprianDaniela Prayer
May 14, 2010·Cold Spring Harbor Perspectives in Biology·Alain Chédotal, Linda J Richards
Mar 2, 2006·Genes, Brain, and Behavior·D WahlstenH S Ozaki
May 21, 2003·Development·Tianzhi ShuLinda J Richards
Oct 24, 2006·AJR. American Journal of Roentgenology·Steven W HettsA James Barkovich
Mar 28, 2013·Neural Plasticity·Mitsuaki NishikimiKazunori Nakajima
Jan 31, 2014·Brain : a Journal of Neurology·Timothy J EdwardsLinda J Richards
Dec 15, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Caroline AlbyTania Attié-Bitach
Aug 26, 2011·Neuroscience Research·Shymaa E BilasyTohru Kataoka
Dec 7, 2010·Trends in Neurosciences·Ryann M FameJeffrey D Macklis
Jan 19, 2010·Psychiatry Research·Olivia A BjorkquistEdward P Riley
Sep 26, 2009·Seminars in Pediatric Neurology·Amber-Lee S Donahoo, Linda J Richards
Jul 28, 2009·Seminars in Perinatology·Orit A Glenn
Apr 29, 2006·Congenital Anomalies·Jun UdagawaHiroki Otani
Jan 22, 2011·Journal of Anatomy·Jesper Riise, Bente Pakkenberg
Jul 24, 2010·The Journal of Comparative Neurology·Randal X MoldrichLinda J Richards
Oct 7, 2006·NeuroImage·Andrew L AlexanderJanet E Lainhart
Feb 7, 2006·Gene Expression Patterns : GEP·Wei-Bin ShenLinda J Richards
Jul 8, 2015·Developmental Neurobiology·Michael A RobichauxChristopher W Cowan
Feb 22, 2012·Developmental Biology·Divya K UnniLinda J Richards
Sep 18, 2013·Neuroscience·E Leyva-Díaz, G López-Bendito
Feb 1, 2015·Neuropsychologia·Jubin AbutalebiBrendan S Weekes
Nov 29, 2005·Developmental Biology·Shubha ToleJean M Hébert
Feb 12, 2013·Developmental Biology·Eleni-Maria AmanitiThomas Theil
Jul 30, 2014·Frontiers in Human Neuroscience·Rodrigo SuárezLinda J Richards

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