PMID: 11309154Apr 20, 2001Paper

A role for complement C5 in organism containment and granulomatous response during murine tuberculosis

Scandinavian Journal of Immunology
J K ActorC Jagannath

Abstract

The molecular mechanisms underlying protective granuloma formation and control of bacterial growth during infection with Mycobacterium tuberculosis (MTB) are not yet completely understood. MTB-infected mice with natural deficiency in complement component C5 are unable to develop productive granulomatous responses, and are impaired in limiting organism growth within the lung. To address the molecular basis for this histologic dysfunction, congenic complement C5-sufficient (B10.D2-H2d H2-T18c Hcl/nSnJ) and complement C5-deficient strains (B10.D2-H2d H2-T18c Hco/oSnJ) congenic mice were infected with Mycobacterium tuberculosis, and cytokine and chemokine responses were examined. Twelve and 28 days after infection, lungs showed elevated messages for multiple inflammatory cytokines in both congenic strains. Interleukin (IL)-12(p40) mRNA was also induced during infection in C5-deficient mice, although levels were significantly decreased compared to C5-sufficient congenics. C5-deficient mice also demonstrated reduced KC, MIP-2, IP-10, and MCP-1 mRNA. The defect may directly involve C5-mediated effects on macrophage responses; C5-deficient bone marrow derived macrophages had significantly reduced secretion of KC, MIP-1 alpha and MIP-2 ...Continue Reading

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Citations

Apr 19, 2002·International Immunopharmacology·Jeffrey K ActorMarian L Kruzel
Sep 26, 2006·The Journal of Parasitology·Shripad PatilA Clinton White
Apr 25, 2006·Immunology·Manuela Flórido, Rui Appelberg
May 18, 2004·FEMS Immunology and Medical Microbiology·Mark A ChambersR Glyn Hewinson
Sep 14, 2012·Clinical & Developmental Immunology·Kerry J WelshJeffrey K Actor
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·D Sundarsingh DanielChinnaswamy Jagannath
Sep 7, 2018·Genes and Immunity·Brigitte GlanzmannCraig J Kinnear

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