A role for dopamine in feeding responses produced by orexigenic agents

Brain Research
Thomas S HnaskoR D Palmiter

Abstract

Dopamine-deficient (DD) mice become hypophagic and die of starvation by 3 to 4 weeks of age unless dopamine is restored by daily treatment with l-3-4-dihydroxyphenylalanine (l-dopa). We demonstrate here that DD mice mount qualitatively normal counter-regulatory blood glucose responses to insulin and 2-deoxy-d-glucose (2-DG). However, unlike control mice, DD mice fail to eat in response to acute glucoprivation induced by insulin or 2-DG. They also have a severely blunted response to central administration of peptide YY (PYY). Viral-mediated restoration of dopamine synthesis to the central caudate putamen (CPu) of DD mice rescues feeding and survival. However, this treatment fails to restore insulin- and 2-DG-induced feeding despite normalizing feeding in response to food deprivation and PYY. Since dopamine signaling in the CPu is not sufficient for glucoprivation-induced feeding, we propose that this feeding behavior may be mediated by dopamine in an anatomically distinct brain region.

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Citations

Aug 4, 2012·Nature Reviews. Drug Discovery·Marcelo O Dietrich, Tamas L Horvath
May 18, 2007·Annual Review of Neuroscience·Qian Gao, Tamas L Horvath
Dec 27, 2005·BMC Neuroscience·Francisco A PerezRichard D Palmiter
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Thomas S HnaskoRichard D Palmiter
Dec 7, 2007·FEBS Letters·Qian Gao, Tamas L Horvath
Sep 26, 2013·The Journal of Physiology·Luis A TellezIvan E de Araujo
Aug 16, 2011·Neuroscience·R D Palmiter
Jan 8, 2011·European Journal of Pharmacology·Qi Wu, Richard D Palmiter
Sep 5, 2009·Frontiers in Neuroendocrinology·Carmen Sánchez-LasherasJens C Brüning
Jul 3, 2007·Trends in Neurosciences·Richard D Palmiter
Dec 30, 2006·Peptides·Serge LuquetRichard D Palmiter
Oct 18, 2005·Brain Research·Bethany N SotakRichard D Palmiter
Dec 21, 2014·Frontiers in Neuroendocrinology·Ulrike StadlbauerUrs Meyer
Sep 20, 2006·Neuron·Alfonso AbizaidTamas L Horvath
May 16, 2021·Proceedings of the National Academy of Sciences of the United States of America·Emilie J RichardsChristopher H Martin

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