Oct 15, 1989

A role for endogenous retroviral sequences in the regulation of lymphocyte activation

The Journal of Immunology : Official Journal of the American Association of Immunologists
A M KriegA D Steinberg

Abstract

The genomes of most vertebrates contain numerous retroviral sequences, the great majority of which are non-infectious. These endogenous retroviral sequences are transcribed and translated in many host tissues, and are induced by mitogens. The function, if any, of endogenous retroviruses has been unclear. The transmembrane envelope proteins of some infectious type C retroviruses suppress lymphocyte activation, but it is unknown whether any endogenous type C retroviruses share this suppressive activity. To study the possible effects of murine endogenous retroviral expression, specific antisense oligonucleotides were synthesized complementary to type C retroviral sequences, and were cultured with murine spleen cells. If any of these endogenous retroviruses are suppressing lymphocyte activation, then inhibiting such endogenous retroviral-mediated suppression with antisense might result in lymphocyte stimulation. Three classes of endogenous type C retroviral sequences may be distinguished by antisense oligonucleotides (based on their homology to infectious retroviruses): ecotropic, xenotropic, and mink cell focus-forming (MCF). Antisense oligonucleotides to endogenous MCF envelope gene (env) initiation regions caused: i) doubling or...Continue Reading

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Mentioned in this Paper

Spleen
Receptors, Antigen, B-Cell
Mice, Inbred NZB
Mice, Inbred DBA
Lymphocyte Activation
Gene Expression Regulation, Viral
Oligonucleotides
Immune-Associated Antigens
Oligonucleotides, Antisense
Rats, Inbred Lew

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