A role for gastrointestinal endotoxins in enhancement of heat tolerance by physical fitness

Journal of Applied Physiology
S Sakurada, J R Hales

Abstract

To further elucidate mechanisms underlying the higher heat tolerance of physically fit compared with sedentary people, we have investigated the possibility that endotoxins (of gastrointestinal origin) act, as in the normal development of fever, to raise body temperature and therefore reduce heat tolerance. In an initial series of experiments, five physically fit and four sedentary sheep were exposed twice at rest to an environment of 42/35 degrees C (dry/wet bulb temperature). When animals were given normal saline i.v., rectal temperature (Tre) rose at a significantly higher rate in sedentary than in fit animals; this confirms that heat tolerance is improved by physical fitness. Treatment with i.v. indomethacin did not affect the rate of rise of Tre in fit animals. In sedentary animals, however, Tre was lowered to approximate that of fit animals. Because indomethacin blocks prostaglandin pathways involved in endotoxin-induced fever, the indomethacin-induced improvement of heat tolerance of sedentary but not fit animals supports the contention that endotoxins play a role in determining that difference in heat tolerance. In a second series of experiments, quantitative cardiovascular measurements were made by using radioactive mic...Continue Reading

References

Oct 1, 1992·Journal of Applied Physiology·A J RyanC V Gisolfi
Apr 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·T MózesI L Bonta
Dec 1, 1991·Journal of Applied Physiology·Y ZurovskiM Horowitz
Jun 1, 1991·Journal of Applied Physiology·A BouchamaS al-Sedairy
Sep 1, 1991·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·J L SkibbaJ H Kalbfleisch
Jun 1, 1985·Prostaglandins, Leukotrienes, and Medicine·F L Anderson, A C Kralios
Mar 1, 1986·Journal of Pharmacobio-dynamics·T ItamiS Kanoh
Jan 1, 1968·Journal of Applied Physiology·W P Marsland
May 1, 1969·Journal of Applied Physiology·C Gisolfi, S Robinson
Jan 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·D A DuBoseJ Rowlands
Jan 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J M Fruth, C V Gisolfi
Feb 1, 1993·The Journal of Physiology·D HullJ McIntyre
Dec 1, 1960·The Journal of Experimental Medicine·T WIZNITZERJ FINE

❮ Previous
Next ❯

Citations

May 27, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew KuennenPope Moseley
Jul 8, 2011·European Journal of Applied Physiology·Heather E WrightTom M McLellan
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Samuel Penna WannerFrancisco Teixeira-Coelho
Sep 10, 2002·Medicine and Science in Sports and Exercise·Peter TikuisisGlen Selkirk
Feb 14, 2004·Journal of Veterinary Pharmacology and Therapeutics·P SotoP J Hansen
Oct 5, 2006·Medicine and Science in Sports and Exercise·Shawnda A MorrisonStephen Cheung
Jun 21, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·G A SelkirkS G Rhind
Jun 10, 2014·International Journal of Sports Physiology and Performance·David B PyneAndrew M Edwards
Jun 21, 2002·The New England Journal of Medicine·Abderrezak Bouchama, James P Knochel
Jul 10, 2004·Exercise and Sport Sciences Reviews·Stephen S Cheung, Gordon G Sleivert
Jul 12, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Stephen S Cheung
Nov 20, 2016·Temperature : Multidisciplinary Biomedical Journal·Nicole Vargas, Frank Marino
Jun 1, 2018·Journal of Sports Medicine·Lawrence E ArmstrongElizabeth M Armstrong
Feb 26, 2008·Current Sports Medicine Reports·Jonathan T Finnoff
Jul 17, 2013·International Journal of Biometeorology·Samuel Penna WannerCândido Celso Coimbra
Jul 2, 2017·Molecular Reproduction and Development·Jason W RossLance H Baumgard
Jan 26, 1999·Annals of the New York Academy of Sciences·J R Hales, S Sakurada
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Carl V. Gisolfi
Jan 2, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carl D BradfordDavid F Gerrard
Jul 30, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Shawnda A MorrisonJames D Cotter
May 5, 2005·Medicine and Science in Sports and Exercise·Jordan BakerRobert J Walker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
M MaskreyA A Fawcett
American Journal of Veterinary Research
G D BottomsH C Frauenfelder
© 2021 Meta ULC. All rights reserved