PMID: 9658125Jul 11, 1998Paper

A role for herpesvirus saimiri orf14 in transformation and persistent infection

Journal of Virology
M DuboiseJ U Jung

Abstract

The product of open reading frame 14 (orf14) of herpesvirus saimiri (HVS) exhibits significant homology with mouse mammary tumor virus superantigen. orf14 encodes a 50-kDa secreted glycoprotein, as shown previously (Z. Yao, E. Maraskovsky, M. K. Spriggs, J. I. Cohen, R. J. Armitage, and M. R. Alderson, J. Immunol. 156:3260-3266, 1996). orf14 expressed from recombinant baculovirus powerfully induces proliferation of CD4-positive cells originating from several different species. To study the role of orf14 in transformation, a mutant form of HVS (HVS Deltaorf14) was constructed with a deletion in the orf14 gene. The transforming potential of HVS Deltaorf14 was tested in cell culture and in common marmosets. Parental HVS subgroup C strain 488 immortalized common marmoset T lymphocytes in vitro to interleukin-2-independent growth, while the HVS Deltaorf14 mutant did not produce such a growth transformation. In addition, HVS Deltaorf14 was nononcogenic in common marmosets. In contrast to other nononcogenic HVS mutant viruses which were repeatedly isolated from peripheral blood mononuclear cells of infected marmosets for more than 5 months, HVS Deltaorf14 did not persist at a high level in vivo. These results demonstrate that orf14 of...Continue Reading

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Jan 28, 1998·Journal of Virology·S M DuboiseJ U Jung

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Citations

Feb 22, 2008·Journal of Virology·Keith R Jerome
Jan 12, 2011·Annual Review of Immunology·Erik BartonSamuel H Speck
Mar 13, 2001·DNA and Cell Biology·L E WehnerU Rüther
Sep 25, 2004·Journal of Cellular Physiology·Alexander Y Tsygankov
Jun 19, 2008·Immunology and Cell Biology·Anja GlanzBrigitte Biesinger
Mar 10, 2001·The Journal of Experimental Medicine·A EnsserB Fleckenstein
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H Fickenscher, B Fleckenstein
Jun 1, 2004·Molecular and Cellular Biology·Sun-Hwa LeeJae U Jung
May 27, 1999·Seminars in Cancer Biology·J U JungB Biesinger
Jul 21, 2004·Virology·Robert E Means

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