A role for ion channels in glioma cell invasion

Neuron Glia Biology
Michael B McFerrin, H Sontheimer

Abstract

Many cells, including neuronal and glial progenitor cells, stem cells and microglial cells, have the capacity to move through the extracellular spaces of the developing and mature brain. This is particularly pronounced in astrocyte-derived tumors, gliomas, which diffusely infiltrate the normal brain. Although a significant body of literature exists regarding signals that are involved in the guidance of cells and their processes, little attention has been paid to cell-shape and cell-volume changes of migratory cells. However, extracellular spaces in the brain are very narrow and represent a major obstacle that requires cells to dynamically regulate their volume. Recent studies in glioma cells show that this involves the secretion of Cl(-) and K(+) with water. Pharmacological inhibition of Cl(-) channels impairs their ability to migrate and limits tumor progression in experimental tumor models. One Cl(-)-channel inhibitor, chlorotoxin, is currently in Phase II clinical trials to treat malignant glioma. This article reviews our current knowledge of cell-volume changes and the role of ion channels during the migration of glioma cells. It also discusses evidence that supports the importance of channel-mediated cell-volume changes in...Continue Reading

Citations

Jul 18, 2016·European Biophysics Journal : EBJ·Emily G Thompson, Harald Sontheimer
Aug 25, 2016·Cellular and Molecular Life Sciences : CMLS·Irina KerkisPaulo L de Sá Junior
Apr 6, 2019·Frontiers in Pharmacology·Mohadeseh DastpeymanNorelle L Daly
Dec 18, 2019·Cellular and Molecular Neurobiology·Daniela RattoPaola Rossi
Jun 12, 2021·Frontiers in Neuroscience·Luke MaggsSoldano Ferrone

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