Abstract
The present study was undertaken to evaluate possible roles of L-glutamate ionotropic receptors in neurogenic pulmonary edema. Perfusion of L-glutamate into the fourth ventricles of rats increased nitric oxide (NO) signals in the efflux solution concentration-dependently, significantly reducing both the occurrence and severity of neurogenic pulmonary edema. This effect was completely reversed by prior intracisternal injection of an NO synthase inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME), or an N-methyl-D-aspartate (NMDA) receptor antagonist, dizocilpine maleate (MK-801), and partially by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA)/kainic acid receptor antagonist. Administration of MK-801 or CNQX alone, without L-glutamate, almost completely prevented neurogenic pulmonary edema development. These results suggest that endogenous L-glutamate may facilitate underlining disease process, whereas L-glutamate exogenously applied into the fourth ventricle may have an inhibitory action via release of NO, through ionotropic receptors.
References
Oct 23, 1992·Science·S Nakanishi
May 10, 1991·Brain Research·J Y Koh, D W Choi
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D S Bredt, S H Snyder
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Jan 1, 1990·Annual Review of Neuroscience·D W Choi, S M Rothman
Oct 17, 1989·European Journal of Pharmacology·J GarthwaiteS Moncada
Jul 1, 1985·Circulation Research·A B Malik
Mar 1, 1988·Japanese Journal of Pharmacology·N IshikawaY Sato
Jan 1, 1994·Progress in Neurobiology·S R Vincent
May 1, 1995·Journal of Neurochemistry·N M JonesP M Beart
Jan 1, 1995·Neuropharmacology·J P Pin, R Duvoisin
Nov 1, 1994·Neuropharmacology·S A Lipton, J S Stamler
Jan 1, 1994·Annual Review of Biophysics and Biomolecular Structure·S Nakanishi, M Masu
Apr 18, 1994·Brain Research·B KoretzD A Greenberg
Mar 19, 1993·Neuroscience Letters·A J Lawrence, B Jarrott
Jan 1, 1994·Annual Review of Neuroscience·M Hollmann, S Heinemann
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Mar 7, 1997·Brain Research·C AokiT M Dawson
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A C RimaniolD Dormont
Jun 8, 2001·Critical Care Medicine·O HamdyN Ishikawa
Sep 25, 2002·The European Journal of Neuroscience·Hadas SchoriMichal Schwartz
Dec 21, 2002·Autonomic Neuroscience : Basic & Clinical·Guo Gang FengNaohisa Ishikawa
Sep 5, 2003·Psychopharmacology·Fabrício Araújo MoreiraFrancisco Silveira Guimarães
Citations
Sep 26, 2007·Journal of Neurotrauma·Jirí SedýEva Syková
Aug 19, 2007·Medical Hypotheses·J SedýE Syková
Aug 19, 2007·Neuroscience Letters·Jirí SedýEva Syková
Dec 17, 2014·Journal of Neurotrauma·Jiří ŠedýJosef Zicha
Aug 14, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jirí SedyEva Syková
Sep 10, 2011·Journal of Applied Physiology·Jirí SedýJaroslav Kunes
Nov 13, 2015·Neurocritical Care·Lili ZhangWenzhi Li
Dec 24, 2011·Physiological Research·J SedýJ Zicha