PMID: 9558444Apr 29, 1998Paper

A role for lipoxygenase metabolites of arachidonic acid in porcine ovulation

Animal Reproduction Science
B R DowneyS E Doyle

Abstract

Prostaglandins, products of arachidonic acid via the cyclooxygenase pathway, are essential to the porcine ovulatory process in that inhibition of their synthesis results in ovulation failure. Studies in the rat have shown that ovulation is also preceded by a rise in three ovarian hydroxyeicosatetraenoic acids, products of the lipoxygenase pathway, and inhibition of this pathway also inhibits ovulation. Experiments were designed, using a pregnant mare serum gonadotropin/human chorionic gonadotropin (hCG)-treated prepuberal gilt model, to measure pre-ovulatory changes in follicular fluid concentrations of 15-hydroxyeicosatetraenoic acid (15-HETE), and to compare the effects of indomethacin and nordihydroguaiaretic acid (NDGA) on ovulation in the pig and on 15-HETE and prostaglandin F2 alpha synthesis both in vivo and in vitro. Follicular fluid concentrations of 15-HETE were elevated significantly just prior to the expected time of ovulation (40 h after hCG). When indomethacin (10 mg) was injected into the ovarian stalk at 24 h after hCG, follicular fluid concentrations of both 15-HETE and prostaglandin F2 alpha were lower (P < 0.01) than controls at 40 h and ovulation rate was suppressed (P < 0.01). When NDGA (5 mg) was administe...Continue Reading

References

Sep 1, 1979·Biology of Reproduction·L AinsworthD T Armstrong
Jul 1, 1991·Endocrinology·Y YoshimuraM Suzuki
Nov 1, 1989·Steroids·W J LeMaire
Feb 1, 1980·Biology of Reproduction·L L Espey
Jan 1, 1980·Prostaglandins·B R Downey, L Ainsworth
Aug 1, 1993·Prostaglandins·W J MurdochL A McPherson

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Citations

Oct 2, 2001·Prostaglandins & Other Lipid Mediators·G Basini, C Tamanini
Jan 16, 2002·Prostaglandins & Other Lipid Mediators·Hiroaki TaniguchiKiyoshi Okuda
Jan 2, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Shiro KurusuMitsumori Kawaminami
Feb 24, 2006·The Veterinary Journal·C W WeemsR D Randel
Jan 13, 2015·General and Comparative Endocrinology·Olivia M Knight, Glen Van Der Kraak
Aug 13, 2004·Biology of Reproduction·Honglin JiangMatthew C Lucy
Jan 19, 2020·Analytical and Bioanalytical Chemistry·Fernanda Bertuccez CordeiroRobert Graham Cooks

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