A role for methanogens and methane in the regulation of GLP-1

Endocrinology, Diabetes & Metabolism
Rose LaverdureJeffrey Gagnon

Abstract

The gastrointestinal (GI) microbiome has emerged as a potential regulator of metabolism. However, the precise mechanisms of how microorganisms may influence physiology remain largely unknown. Interestingly, GI microorganisms, including methanogens, are localized within the same regions as the glucagon-like peptide-1 (GLP-1) secreting L cells. GLP-1 plays key roles appetite and glucose regulation. Furthermore, both methane and GLP-1 levels are altered in obese humans with metabolic disease. We predict that high-fat diet-induced obesity alters the abundance of GI methanogens and that methane may play a role in the GLP-1 secretory response from the L cell. To demonstrate this, GLP-1 secretion response and faecal methanogens were examined in mice given a high-fat diet for 14 weeks. In addition, the direct effect of methane on GLP-1 secretion was assessed in two L-cell models (NCI-H716 and GLUTag). High-fat diet caused a significant increase in both GLP-1 secretion and faecal methanogen content. There was a direct correlation between GLP-1 secretion response and faecal methanogen levels. In L cells, methane stimulated GLP-1 secretion and enhanced intracellular cAMP content. These results indicate that alterations in the methanogen c...Continue Reading

References

Dec 2, 2008·Nature·Peter J TurnbaughJeffrey I Gordon
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Oct 3, 2012·Nature Reviews. Gastroenterology & Hepatology·Charlotte X Dong, Patricia L Brubaker
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Sep 7, 2013·Science·Vanessa K RidauraJeffrey I Gordon
Aug 14, 2015·Endocrinology·Jeffrey GagnonPatricia L Brubaker
Jan 9, 2016·The Journal of Clinical Endocrinology and Metabolism·Hannes ManellPeter Bergsten

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Citations

Sep 7, 2019·Journal of Zhejiang University. Science. B·Er-Teng JiaQin-Yu Ge
Jul 22, 2020·Nature Reviews. Microbiology·Guillaume BorrelChristine Moissl-Eichinger
Jun 15, 2019·International Journal of Molecular Sciences·Ziguo SongChao Sun

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Methods Mentioned

BETA
PCR
ELISA

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