A Role for Mouse Primary Visual Cortex in Motion Perception

Current Biology : CB
Tiago MarquesLeopoldo Petreanu

Abstract

Visual motion is an ethologically important stimulus throughout the animal kingdom. In primates, motion perception relies on specific higher-order cortical regions. Although mouse primary visual cortex (V1) and higher-order visual areas show direction-selective (DS) responses, their role in motion perception remains unknown. Here, we tested whether V1 is involved in motion perception in mice. We developed a head-fixed discrimination task in which mice must report their perceived direction of motion from random dot kinematograms (RDKs). After training, mice made around 90% correct choices for stimuli with high coherence and performed significantly above chance for 16% coherent RDKs. Accuracy increased with both stimulus duration and visual field coverage of the stimulus, suggesting that mice in this task integrate motion information in time and space. Retinal recordings showed that thalamically projecting On-Off DS ganglion cells display DS responses when stimulated with RDKs. Two-photon calcium imaging revealed that neurons in layer (L) 2/3 of V1 display strong DS tuning in response to this stimulus. Thus, RDKs engage motion-sensitive retinal circuits as well as downstream visual cortical areas. Contralateral V1 activity played...Continue Reading

Citations

Jul 19, 2018·The European Journal of Neuroscience·Rafiq HudaMriganka Sur
Sep 27, 2018·Journal of Neurophysiology·Brice WilliamsBilal Haider
Dec 13, 2019·Cerebral Cortex·Shaun L ClohertyJude F Mitchell
Apr 26, 2020·Nature Communications·Wen-Kai You, Shreesh P Mysore
Jul 18, 2020·Nature Communications·Kevin K Sit, Michael J Goard
Aug 11, 2018·Annual Review of Vision Science·Wei Wei
Mar 28, 2020·Current Protocols in Neuroscience·Richard J KrauzlisLupeng Wang
Jan 14, 2021·Cell Reports·Manavu TohmiJianhua Cang
Mar 4, 2021·Journal of Neurophysiology·Benedict Wild, Stefan Treue
Apr 30, 2021·Annual Review of Neuroscience·Cristopher M Niell, Massimo Scanziani
Aug 5, 2020·Current Biology : CB·Rune Rasmussen, Keisuke Yonehara
Sep 15, 2021·PLoS Computational Biology·Giulio MatteucciDavide Zoccolan
Sep 30, 2020·Mathematical Biosciences and Engineering : MBE·Li Qin Liu, Chun Rui Zhang
Dec 1, 2021·Brain Structure & Function·Răzvan Gămănuţ, Daisuke Shimaoka

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