A role for nitric oxide in X-ray contrast material toxicity

Academic Radiology
E C LasserS G Lyon

Abstract

We assessed the role that nitric oxide (NO) plays in contrast media (CM) toxicity, using 100% lethal dose (LD100) studies in hyperimmune Brown Norway (BN) rats. Ninety-two BN rats and 41 Sprague-Dawley (SD) rats underwent CM LD100 tail vein injections with methylglucamine iothalamate or sodium iothalamate to the point of cessation of respiration. Methylglucamine hydrochloride also was injected. The injections were accompanied by L-arginine (L-Arg) or D-arginine (D-Arg) analogues or by an H1 blocker. L-Arg analogues inhibit NO formation, and D-Arg analogues do not. An L-Arg analogue, but not a D-Arg analogue, increased the tolerance of BN rats (p < .005) for methylglucamine iothalamate but not for sodium iothalamate. The L-Arg analogue also protected BN rats against methylglucamine chloride injections (p < .002). H1 blockade protected BN rats against methylglucamine iothalamate (p < .0005) and methylglucamine chloride (p < .005) injections. None of these measures altered the CM tolerance of SD rats. In SD rats, injections of either methylglucamine iothalamate or sodium iothalamate along with a D-Arg analogue or normal saline were better tolerated than similar injections in BN rats (p < .01 and .002 for methylglucamine iothalamat...Continue Reading

References

Mar 1, 1979·Scandinavian Journal of Immunology·T KarlssonH Bennich
Jan 1, 1992·International Archives of Allergy and Immunology·W ElwoodK F Chung
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W RadomskiS Moncada
Sep 1, 1971·Radiology·E C LasserJ Lang
Jul 18, 1974·The New England Journal of Medicine·L M ZirR S Lees
Jul 1, 1983·The Journal of Allergy and Clinical Immunology·E C LasserS D Revak
Jun 1, 1984·The British Journal of Radiology·D H Carr, A C Walker
Nov 1, 1980·Investigative Radiology·G AnsellL Couch
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jun 1, 1994·Investigative Radiology·E C Lasser, G E Lamkin
Feb 11, 1994·European Journal of Pharmacology·S OsadaM Semma

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Citations

May 22, 2002·Academic Radiology·E C Lasser, G E Lamkin
Dec 26, 2001·Investigative Radiology·Wakako FurutaYasufumi Kataoka
Oct 11, 2012·Polish journal of radiology·Tomasz Kun, Lucjusz Jakubowski
Aug 1, 1996·Academic Radiology·E C LasserS Lyon
Oct 27, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G Deray

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