PMID: 9160291Apr 1, 1997Paper

A role for photoproducts of vitamin D in the etiology of cutaneous melanoma?

Medical Hypotheses
M M Braun, M A Tucker

Abstract

Several clinical and epidemiological aspects of cutaneous melanoma seem anomalous because they contrast with other sunlight-associated skin cancers. For example, persons with the greatest risk of melanoma are not those with the greatest cumulative solar exposure, the anatomic areas that receive the most solar exposure are not preferentially affected, and the incidence of the disease is seasonal, with more cases reported in summer than winter. This article discusses the synthesis and biologic effects of vitamin D photoproducts and suggests that sun-related local skin effects, mediated by vitamin D photoproducts, on melanocytes previously damaged by excessive solar exposure may help explain the seemingly anomalous aspects of melanoma.

References

Jan 1, 1992·Clinics in Dermatology·J M Elwood
Mar 1, 1991·Physics in Medicine and Biology·B L Diffey
Jul 18, 1991·The New England Journal of Medicine·H K Koh
May 1, 1989·The Journal of Clinical Endocrinology and Metabolism·A R WebbM F Holick
Oct 1, 1985·The Journal of Clinical Investigation·J MacLaughlin, M F Holick
Nov 1, 1980·Age and Ageing·M R BakerB E Nordin
May 1, 1981·American Journal of Public Health·M W HindsL N Kolonel
Aug 1, 1994·Melanoma Research·M M BraunR N Hoover

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Citations

Jul 19, 2005·The British Journal of Nutrition·Viraj J JasinghePhilip J Barlow
Mar 21, 2006·Progress in Biophysics and Molecular Biology·William B Grant

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