A Role for Ploidy in Heart Regeneration

Developmental Cell
Zachary A Kadow, James F Martin

Abstract

There is mounting circumstantial evidence that ploidy, a cell's relative DNA content, is in part responsible for the differential cardiac regenerative capacity observed between regenerative and non-regenerative organisms. In this issue of Developmental Cell, González-Rosa et al. (2018) provide direct evidence that polyploid cardiomyocytes have reduced proliferative and regenerative potential.

Citations

Jul 3, 2019·Trends in Endocrinology and Metabolism : TEM·Kathleen M Broughton, Mark A Sussman

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