PMID: 6329483Apr 1, 1984Paper

A role for presynaptic alpha 2-adrenoceptors in angiotensin II-induced drinking in rats

Brain Research Bulletin
M J FreglyJ E Greenleaf


Studies from this laboratory have shown that either central or peripheral administration of clonidine, the alpha 2-adrenoceptor agonist, can attenuate a variety of dipsogenic stimuli in rats. Further, yohimbine and tolazoline, alpha 2-adrenoceptor antagonists, augment the drinking response to both peripherally administered isoproterenol and angiotensin II. Studies reported here establish a dose-inhibition relationship between the dose of clonidine administered (2 to 32 micrograms/kg) intracerebroventricularly (IVT) and inhibition of the drinking response to peripherally administered angiotensin II (200 micrograms/kg. SC). DI50 was approximately 4 micrograms/kg. Yohimbine (300 micrograms/kg, SC) reversed the antidipsogenic effect of centrally administered clonidine (32 micrograms/kg, IVT) on angiotensin II-induced (200 micrograms/kg, SC) water intake. Phenylephrine, an alpha 2-adrenoceptor agonist, administered IVT (40 and 80 micrograms/kg) also inhibited angiotensin II-induced drinking in a dose-related fashion. The antidipsogenic effect of phenylephrine (80 micrograms/kg) was blocked by administration of yohimbine (300 micrograms/kg. SC). Thus, this effect of phenylephrine most likely occurs by way of alpha 2-adrenoceptors. Th...Continue Reading


Jun 1, 1979·European Journal of Pharmacology·J A Garcia-SevillaS Z Langer
Jan 1, 1971·Pharmacology·W B SeversJ D Connor
Apr 30, 1984·Brain Research·M J FreglyJ E Greenleaf
Sep 1, 1983·Pharmacology, Biochemistry, and Behavior·D C KiktaJ E Greenleaf
Mar 1, 1984·Appetite·K M WilsonM J Fregly
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·R M ThreatteD C Kikta
Sep 1, 1981·Physiology & Behavior·J A Hosutt, E M Stricker

❮ Previous
Next ❯


Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·E ColombariJ V Menani
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·J C CalleraW A Saad
Jul 1, 1985·Peptides·K M Wilson, M J Fregly
Dec 4, 2003·Brain Research·Lisandra Brandino de OliveiraJosé Vanderlei Menani
Nov 12, 2002·Brain Research·Lisandra Oliveira MargathoJosé Vanderlei Menani
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·L A De LucaE W Meyer
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nicholas J DelvaJames A Owen
Jul 29, 1999·Brain Research Bulletin·J V MenaniL A De Luca
Mar 28, 2009·European Journal of Pharmacology·Carina A F de AndradeJosé V Menani
Feb 13, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C A F AndradeJ V Menani
Aug 22, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M SugawaraL A De Luca
Apr 1, 1990·Psychological Reports·D F Greenwald
Aug 1, 1989·Psychological Reports·D F Greenwald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.