PMID: 6329483Apr 1, 1984Paper

A role for presynaptic alpha 2-adrenoceptors in angiotensin II-induced drinking in rats

Brain Research Bulletin
M J FreglyJ E Greenleaf

Abstract

Studies from this laboratory have shown that either central or peripheral administration of clonidine, the alpha 2-adrenoceptor agonist, can attenuate a variety of dipsogenic stimuli in rats. Further, yohimbine and tolazoline, alpha 2-adrenoceptor antagonists, augment the drinking response to both peripherally administered isoproterenol and angiotensin II. Studies reported here establish a dose-inhibition relationship between the dose of clonidine administered (2 to 32 micrograms/kg) intracerebroventricularly (IVT) and inhibition of the drinking response to peripherally administered angiotensin II (200 micrograms/kg. SC). DI50 was approximately 4 micrograms/kg. Yohimbine (300 micrograms/kg, SC) reversed the antidipsogenic effect of centrally administered clonidine (32 micrograms/kg, IVT) on angiotensin II-induced (200 micrograms/kg, SC) water intake. Phenylephrine, an alpha 2-adrenoceptor agonist, administered IVT (40 and 80 micrograms/kg) also inhibited angiotensin II-induced drinking in a dose-related fashion. The antidipsogenic effect of phenylephrine (80 micrograms/kg) was blocked by administration of yohimbine (300 micrograms/kg. SC). Thus, this effect of phenylephrine most likely occurs by way of alpha 2-adrenoceptors. Th...Continue Reading

References

Jun 1, 1979·European Journal of Pharmacology·J A Garcia-SevillaS Z Langer
Jan 1, 1971·Pharmacology·W B SeversJ D Connor
Apr 30, 1984·Brain Research·M J FreglyJ E Greenleaf
Sep 1, 1983·Pharmacology, Biochemistry, and Behavior·D C KiktaJ E Greenleaf
Mar 1, 1984·Appetite·K M WilsonM J Fregly
Mar 1, 1981·Pharmacology, Biochemistry, and Behavior·R M ThreatteD C Kikta
Sep 1, 1981·Physiology & Behavior·J A Hosutt, E M Stricker

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Citations

Aug 1, 1990·Pharmacology, Biochemistry, and Behavior·E ColombariJ V Menani
Sep 1, 1993·Pharmacology, Biochemistry, and Behavior·J C CalleraW A Saad
Jul 1, 1985·Peptides·K M Wilson, M J Fregly
Dec 4, 2003·Brain Research·Lisandra Brandino de OliveiraJosé Vanderlei Menani
Nov 12, 2002·Brain Research·Lisandra Oliveira MargathoJosé Vanderlei Menani
Apr 20, 1999·Pharmacology, Biochemistry, and Behavior·L A De LucaE W Meyer
Jan 31, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nicholas J DelvaJames A Owen
Jul 29, 1999·Brain Research Bulletin·J V MenaniL A De Luca
Mar 28, 2009·European Journal of Pharmacology·Carina A F de AndradeJosé V Menani
Feb 13, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C A F AndradeJ V Menani
Aug 22, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A M SugawaraL A De Luca
Apr 1, 1990·Psychological Reports·D F Greenwald
Aug 1, 1989·Psychological Reports·D F Greenwald

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