A role for prostaglandin E in defective insulin secretion and carbohydrate intolerance in diabetes mellitus

The Journal of Clinical Investigation
R P Robertson, M Chen


Prostaglandin E(2) (PGE(2)) infusion in normal humans inhibited acute insulin responses to a glucose (5 g i.v.) pulse (response before PGE(2) = 593 +/- 104%; during PGE(2) = 312+/-55%; mean+/-SE, mean change 3-5 min insulin,% basal, P < 0.005). This effect was associated with a decrease in glucose disappearance rates (K(G) before PGE(2) = 0.73+/-0.07; during PGE(2) = 0.49+/-0.06%/min, P < 0.025). Acute insulin responses to arginine (2 g i.v.) were not affected by PGE(2) (response before PGE(2) = 592+/-164%; during PGE(2) = 590+/-118%; P = NS). Infusion of sodium salicylate (SS), an inhibitor of endogenous prostaglandin synthesis, augmented acute insulin responses to glucose in normals (response before SS = 313+/-62%; during SS = 660+/-86%; P < 0.001). In adult-onset diabetes with fasting hyperglycemia, SS restored absent acute insulin responses to glucose (20 g i.v.) pulses (response before SS = 5+/-6%; during SS = 97+/-24%; P < 0.005). This was accompanied by a fourfold augmentation in second phase insulin secretion (second phase before SS = 1,696+/-430%; during SS = 5,176+/-682%; change 10-60 min insulin, muU/ml.min,% basal, P < 0.001) and by acceleration of glucose disappearance rates (K(G) before SS = 0.56+/-0.06; during SS...Continue Reading


Sep 1, 1976·The Journal of Clinical Investigation·J P PalmerJ W Ensinck
Mar 11, 1976·The Journal of Clinical Investigation·R P RobertsonD Porte
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Nov 1, 1972·Biochemical and Biophysical Research Communications·M Hamberg
Apr 1, 1973·The Journal of Clinical Investigation·R P Robertson, D Porte
Aug 1, 1974·The Journal of Clinical Investigation·R P RobertsonE L Bierman
Sep 1, 1971·The Journal of Clinical Endocrinology and Metabolism·R L Lerner, D Porte
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Mar 1, 1992·Journal of Cellular Biochemistry·R P Robertson
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