A role for prostaglandin E in defective insulin secretion and carbohydrate intolerance in diabetes mellitus

The Journal of Clinical Investigation
R P Robertson, M Chen

Abstract

Prostaglandin E(2) (PGE(2)) infusion in normal humans inhibited acute insulin responses to a glucose (5 g i.v.) pulse (response before PGE(2) = 593 +/- 104%; during PGE(2) = 312+/-55%; mean+/-SE, mean change 3-5 min insulin,% basal, P < 0.005). This effect was associated with a decrease in glucose disappearance rates (K(G) before PGE(2) = 0.73+/-0.07; during PGE(2) = 0.49+/-0.06%/min, P < 0.025). Acute insulin responses to arginine (2 g i.v.) were not affected by PGE(2) (response before PGE(2) = 592+/-164%; during PGE(2) = 590+/-118%; P = NS). Infusion of sodium salicylate (SS), an inhibitor of endogenous prostaglandin synthesis, augmented acute insulin responses to glucose in normals (response before SS = 313+/-62%; during SS = 660+/-86%; P < 0.001). In adult-onset diabetes with fasting hyperglycemia, SS restored absent acute insulin responses to glucose (20 g i.v.) pulses (response before SS = 5+/-6%; during SS = 97+/-24%; P < 0.005). This was accompanied by a fourfold augmentation in second phase insulin secretion (second phase before SS = 1,696+/-430%; during SS = 5,176+/-682%; change 10-60 min insulin, muU/ml.min,% basal, P < 0.001) and by acceleration of glucose disappearance rates (K(G) before SS = 0.56+/-0.06; during SS...Continue Reading

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Citations

Mar 1, 1992·Journal of Cellular Biochemistry·R P Robertson
Feb 9, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Fang FangXue-Feng Yu
Jan 1, 1990·Life Sciences·C K LardinoisE L Mazzaferri
Jun 1, 1980·Prostaglandins·A SzczeklikR Nizankowski
Mar 1, 1981·Prostaglandins·C PatronoS Chierchia
Jan 1, 1981·Prostaglandins·A Dembińska-KiećT Zelazny
Mar 1, 1983·Prostaglandins·Y C Kim, R G Brodows
Apr 1, 1980·Prostaglandins and Medicine·S A MetzR P Robertson
Jan 1, 1981·Pharmacology & Therapeutics·B L Furman
Jan 1, 1984·Pharmacology & Therapeutics·R P Robertson
Nov 1, 1983·Prostaglandins, Leukotrienes, and Medicine·H HorieS Tarui
Dec 27, 1979·The New England Journal of Medicine·R P Robertson, S A Metz
Aug 17, 2006·Nutritional Neuroscience·Sam J Bhathena
May 1, 2004·Journal of Medicinal Food·S RajasekaranS Subramanian
Nov 1, 1978·The Journal of Clinical Investigation·R P Robertson, R J Guest
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·C H SorliR P Robertson
Sep 1, 1995·Journal of Endocrinological Investigation·H ShimizuY Shimomura
Jun 21, 2014·Experimental & Molecular Medicine·Michelle E KimplePatrick J Casey
Sep 20, 1979·World Journal of Surgery·B M Jaffe
May 1, 1980·Metabolism: Clinical and Experimental·H E Lebovitz, M N Feinglos
Dec 1, 1979·Prostaglandins and Medicine·J S Goodwin
Feb 1, 1985·Metabolism: Clinical and Experimental·J D MillerM A Sperling
Feb 1, 1979·Prostaglandins and Medicine·D GiuglianoM Varricchio
Mar 1, 1981·Prostaglandins and Medicine·D GiuglianoF D'Onofrio

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