A role for purinergic receptors at the inner hair cell-afferent synapse?

Audiology & Neuro-otology
Donald Robertson, Bardia Paki

Abstract

Previously published evidence is reviewed for a functional role of ATP and its receptors at the chemical synapse between the mammalian inner hair cell and the primary afferent dendrites of the VIIIth nerve. New findings are also presented, both from gross cochlear potentials and single neurone recordings during intracochlear perfusion of ATP-receptor antagonists and agonists. Both the previous and present results are consistent with the notion that endogenous ATP may act to regulate the excitability of the primary afferent dendrite, possibly acting on P2X2 receptors.

Citations

May 26, 2004·Hearing Research·G D SearchfieldP R Thorne
Sep 5, 2002·Hearing Research·Srdjan M VlajkovicGary D Housley
Sep 19, 2003·Hearing Research·T SuetaD Robertson
Feb 24, 2009·Trends in Neurosciences·Gary D HousleyAndreas Reichenbach
Oct 20, 2007·Journal of Neuroscience Methods·P SellickD Robertson
Oct 24, 2002·Neuroreport·Leif E JärlebarkPeter R Thorne
Jul 3, 2009·Journal of Neurophysiology·Ivan MilenkovicRudolf Rübsamen
Jun 21, 2019·International Journal of Molecular Sciences·László KölesTibor Zelles

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