A role for siRNA in X-chromosome dosage compensation in Drosophila melanogaster.

Genetics
Debashish U Menon, V H Meller

Abstract

Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin.

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Citations

Nov 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Debashish U MenonVictoria H Meller
Dec 4, 2015·Annual Review of Genetics·Victoria H MellerNikita Deshpande
Sep 15, 2015·RNA Biology·Debashish U Menon, Victoria H Meller
Jul 2, 2014·Biochimica Et Biophysica Acta·Marta Kostrouchova, Zdenek Kostrouch
Mar 10, 2015·Fly·Nikita Deshpande, Victoria H Meller
Jul 28, 2015·Fly·Steven P Vensko, Eric A Stone
Aug 31, 2013·Transcription·Simona CugusiJohn C Lucchesi
Apr 7, 2018·Molecular Ecology·Michael J O'Neill, Rachel J O'Neill
Feb 14, 2020·Nature Reviews. Genetics·Michael J Gutbrod, Robert A Martienssen
Nov 28, 2013·G3 : Genes - Genomes - Genetics·Manasi S ApteVictoria H Meller
Mar 29, 2020·Briefings in Functional Genomics·Saeed SoleimaniSadegh Azimzadeh Jamalkandi
May 21, 2020·Frontiers in Cell and Developmental Biology·Aleksei S ShatskikhLudmila V Olenina
Feb 11, 2021·Genome Research·Mahul ChakrabortyJ J Emerson
Jan 17, 2016·Genes & Development·Jeffrey J QuinnHoward Y Chang

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Methods Mentioned

BETA
acetylation
PCR

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