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A role for SUMOylation in the Formation and Cellular Localization of TDP-43 Aggregates in Amyotrophic Lateral Sclerosis

Molecular Neurobiology

Nov 15, 2019

Cindy MaurelPatrick Vourc'h

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Abstract

In amyotrophic lateral sclerosis, motor neurons undergoing degeneration are characterized by the presence of cytoplasmic aggregates containing TDP-43 protein. SUMOylation, a posttranslational modification of proteins, has been previously implicated in the formation of aggregates positiv...read more

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Amyotrophic Lateral Sclerosis
Cell Nucleus
Cell Survival
Cu-Zn Superoxide Dismutase
Cytoplasm
Motor Neurons
Nerve Degeneration
Mutagenesis Process
Intracellular
Site
1
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A role for SUMOylation in the Formation and Cellular Localization of TDP-43 Aggregates in Amyotrophic Lateral Sclerosis

Molecular Neurobiology

Nov 15, 2019

Cindy MaurelPatrick Vourc'h

PMID: 31728929

DOI: 10.1007/s12035-019-01810-7

Abstract

In amyotrophic lateral sclerosis, motor neurons undergoing degeneration are characterized by the presence of cytoplasmic aggregates containing TDP-43 protein. SUMOylation, a posttranslational modification of proteins, has been previously implicated in the formation of aggregates positiv...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Cell Nucleus
Cell Survival
Cu-Zn Superoxide Dismutase
Cytoplasm
1

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