PMID: 8946259Dec 1, 1996Paper

A role for the circadian clock of the suprachiasmatic nuclei in the interpretation of serial melatonin signals in the Syrian hamster

Journal of Biological Rhythms
J Grosse, M H Hastings

Abstract

Seasonal rhythms of reproduction in the Syrian hamster are triggered by the pineal hormone melatonin. By varying the parameters of systemic infusions of exogenous melatonin delivered to pinealectomized hamsters, it has been shown that the hypothalamus is sensitive to the duration of individual signals, which serve as an inverse coding of day length. It also has been shown that animals are sensitive to the temporal structure of a series of signals insofar as a series of melatonin infusions of appropriate number and duration may fail to invoke a gonadal response if they are presented at inappropriate frequencies. Although the endogenous circadian pacemaker of the suprachiasmatic nucleus (SCN) is not thought to be involved in the measurement of or response to melatonin signal duration, its contribution to the interpretation of a series of melatonin signals remains to be determined. Syrian hamsters are able to show a short-day-like gonadal response to a series of melatonin signals delivered on a variety of noncircadian schedules, including one in which a "random" pattern of infusions is employed. This study investigated the role of the SCN in the interpretation of such infusion paradigms. Adult male Syrian hamsters received electro...Continue Reading

References

Sep 1, 1965·The Anatomical Record·R A Hoffman, R J Reiter

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Citations

Aug 10, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Matthew J PaulWilliam J Schwartz
Mar 5, 1998·Journal of Biological Rhythms·M V Guerin, C D Matthews
Jul 23, 1998·Physiological Reviews·J Vanecek

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