A role for the interoceptive insular cortex in the consolidation of learned fear

Behavioural Brain Research
José Patricio CasanovaFernando Torrealba

Abstract

A growing body of evidence suggests that learned fear may be related to the function of the interoceptive insular cortex. Using an auditory fear conditioning paradigm in rats, we show that the inactivation of the posterior insular cortex (pIC), the target of the interoceptive thalamus, prior to training produced a marked reduction in fear expression tested 24h later. Accordingly, post-training anisomycin infused immediately, but not 6h after, also reduced fear expression tested the following day, supporting a role for the pIC in consolidation of fear memory. The long-term (ca. a week) and reversible inactivation of the pIC with the sodium channel blocker neosaxitoxin, immediately after fear memory reactivation induced a progressive decrease in the behavioral expression of conditioned fear. In turn, we observed that fear memory reactivation is accompanied by an enhanced expression of Fos and Zif268, early genes involved in neural activity and plasticity. Taken together these data indicate that the pIC is involved in the regulation of fear memories.

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Citations

Aug 16, 2016·Neurobiology of Learning and Memory·Allison R FoilbJohn P Christianson
Jun 4, 2018·Sleep·Jeehye SeoEdward F Pace-Schott
Oct 31, 2019·Human Brain Mapping·Virginie SterpenichSophie Schwartz
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Jan 31, 2020·Frontiers in Behavioral Neuroscience·María RodríguezMarco Contreras
Apr 16, 2019·Frontiers in Physiology·Maxs Méndez-RuetteJimmy Stehberg
Feb 14, 2021·Neurobiology of Learning and Memory·Joselisa Peres Queiroz de PaivaR V Fornari
Apr 3, 2021·Neurobiology of Learning and Memory·C X Ruiz-LópezR A Prado-Alcalá
Feb 27, 2016·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Yunqi ZhuMei Tian
Aug 31, 2021·Neuropharmacology·Samuel W CentanniFrederic W Hopf
Nov 19, 2021·Science·Alexandra S KleinNadine Gogolla

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