A role for the periaqueductal gray in switching adaptive behavioral responses

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
M H SukikaraN S Canteras

Abstract

Previous studies suggested a role for the rostral lateral periaqueductal gray (PAG) in the inhibition of maternal behavior induced by low doses of morphine in dams with previous morphine experience. In the present study, we first showed that unilateral NMDA lesions placed in this particular PAG region prevented the morphine-induced inhibition of maternal behavior in previously morphine-sensitized dams. As suggested by previous Fos data on the PAG, predatory hunting appears as a likely candidate to replace maternal behavior in the morphine-treated dams. By testing saline- and morphine-treated dams with live cockroaches only, we have presently shown that morphine challenge increased insect hunting. Moreover, morphine- and saline-treated dams were also observed in an environment containing pups and roaches. Although most of the saline-treated animals displayed active nursing and only occasionally presented insect hunting, all of the morphine-treated animals ignored the pups and avidly pursued and caught the roaches. We next questioned whether the rostral lateral PAG would be involved in this behavioral switch. Our results showed that unilateral lesions of the rostral lateral PAG, but not other parts of the PAG, partially impaired ...Continue Reading

Citations

Dec 13, 2007·Nature Reviews. Neuroscience·Paula J Brunton, John A Russell
Sep 6, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anders NelsonRichard Mooney
May 30, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E TeodorovL F Felício
Jan 15, 2014·Journal of Chemical Neuroanatomy·Geraldine K E GoebrechtJ Matthew Kittelberger
May 31, 2013·Social Cognitive and Affective Neuroscience·Christine E ParsonsMorten L Kringelbach
Mar 7, 2012·The Journal of Physiology·Heather B MadsenAndrew J Lawrence
Jan 1, 2015·Pharmacology, Biochemistry, and Behavior·A M CruzL F Felicio
Sep 10, 2011·Behavioural Brain Research·Sandra Regina Mota-OrtizNewton Sabino Canteras
Mar 19, 2011·Neuroscience and Biobehavioral Reviews·Stephen M Siviy, Jaak Panksepp
Apr 27, 2010·Physiology & Behavior·Aline de Mello CruzLuciano F Felicio
Feb 9, 2010·Behavioural Brain Research·Marcia Harumi SukikaraNewton Sabino Canteras
Oct 24, 2007·Peptides·Richard J Bodnar
Jul 13, 2007·Pharmacology, Biochemistry, and Behavior·Marcia H SukikaraLuciano F Felicio
Jan 20, 2007·Physiology & Behavior·Lucélia M dos SantosNewton S Canteras
Apr 25, 2015·Neuroscience and Biobehavioral Reviews·Stephanie L Brown, R Michael Brown
Oct 15, 2009·Neuroscience·I C FurigoN S Canteras
Sep 22, 2007·The European Journal of Neuroscience·Elolsa PavesiMariana Graciela Terenzi
Jul 25, 2012·The Journal of Comparative Neurology·J Matthew Kittelberger, Andrew H Bass
Apr 11, 2012·The Journal of Comparative Neurology·Joel D Hahn, Larry W Swanson
Jun 24, 2011·Journal of Neuroendocrinology·M H SukikaraL F Felicio
Jul 15, 2015·Hearing Research·Alessia PanneseSascha Frühholz
Aug 15, 2014·Behavioural Brain Research·Marianne Orlandini KleinLuciano Freitas Felicio
Nov 9, 2011·Physiology & Behavior·Lucélia Mendes dos SantosNewton Sabino Canteras
Jun 14, 2016·The Journal of Comparative Neurology·Alessandro BilellaMarco R Celio
Dec 3, 2008·Neuroscience and Biobehavioral Reviews·Seyed M AssadiChristos Pantelis
Aug 31, 2010·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·L M MouraL F Felicio
Nov 14, 2006·Behavioral and Cognitive Neuroscience Reviews·Michael Numan
Jul 28, 2011·Journal of Neuroendocrinology·C H Kinsley, E Amory-Meyer
Jan 10, 2020·The International Journal of Neuroscience·T Mendes-LimaM M Bernardi
Nov 12, 2018·Cell and Tissue Research·Paula J Brunton
Sep 14, 2018·Frontiers in Behavioral Neuroscience·Valerie Lee Tryon, Sheri J Y Mizumori
May 28, 2019·Frontiers in Behavioral Neuroscience·Tamara B Franklin
Sep 17, 2016·Learning & Memory·Bianca A SilvaJohannes Gräff
Aug 8, 2020·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Anthony G VaccaroAntonio Damasio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.