A role for the ubiquitin-proteasome system in activity-dependent presynaptic silencing.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Xiaoping JiangKrista L Moulder

Abstract

Chronic changes in electrical excitability profoundly affect synaptic transmission throughout the lifetime of a neuron. We have previously explored persistent presynaptic silencing, a form of synaptic depression at glutamate synapses produced by ongoing neuronal activity and by strong depolarization. Here we investigate the involvement of the ubiquitin-proteasome system (UPS) in the modulation of presynaptic function. We found that proteasome inhibition prevented the induction of persistent presynaptic silencing. Specifically, application of the proteasome inhibitor MG-132 (carbobenzoxy-L-leucyl-L-leucyl-L-leucinal) prevented decreases in the size of the readily releasable pool of vesicles and in the percentage of active synapses. Presynaptic silencing was accompanied by decreases in levels of the priming proteins Munc13-1 and Rim1. Importantly, overexpression of Rim1alpha prevented the induction of persistent presynaptic silencing. Furthermore, strong depolarization itself increased proteasome enzymatic activity measured in cell lysates. These results suggest that modulation of the UPS by electrical activity contributes to persistent presynaptic silencing by promoting the degradation of key presynaptic proteins.

References

Sep 1, 1999·Proceedings of the National Academy of Sciences of the United States of America·L MengC M Crews
Nov 30, 2000·Archives of Biochemistry and Biophysics·M Orlowski, S Wilk
Jun 19, 2002·Proceedings of the National Academy of Sciences of the United States of America·Frederique VaroqueauxChristian Rosenmund
Dec 5, 2003·Current Biology : CB·Gentry N PatrickErin M Schuman
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hong ChenPietro V De Camilli
Dec 17, 2003·Cell·Fengxue ZhangJeffrey E Kudlow
Jan 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julian P Meeks, Steven Mennerick
Jan 22, 2004·Nature Reviews. Neuroscience·Gina G Turrigiano, Sacha B Nelson
May 12, 2004·Neuron·Krista L MoulderSteven Mennerick
Sep 21, 2004·Annual Review of Plant Biology·Jan Smalle, Richard D Vierstra
Apr 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krista L Moulder, Steven Mennerick
Oct 26, 2005·Biochemical Society Transactions·P S Kaeser, T C Südhof
Dec 15, 2005·Neurochemistry International·Sudarshan C UpadhyaAshok N Hegde
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krista L MoulderSteven Mennerick
Aug 22, 2006·Experimental Neurology·Stephen H ReaneyDonato A Di Monte
Aug 23, 2006·Journal of Neurochemistry·William J PottorfStanley A Thayer
Nov 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristen WilleumierFelix E Schweizer
Dec 15, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefan KallaNils Brose
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jonathan T TingJane M Sullivan
Jun 15, 2007·The Journal of Biological Chemistry·Fengxue ZhangJeffrey E Kudlow
Sep 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krista L MoulderSteven Mennerick
Oct 24, 2007·Trends in Neurosciences·Ashok N Hegde, Sudarshan C Upadhya
Nov 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard S SalibaStephen J Moss
Dec 13, 2007·Physiology·Fengxue ZhangJeffrey E Kudlow
Jan 29, 2008·Biochimica Et Biophysica Acta·Kevin F Haas, Kendal Broadie
Apr 26, 2008·Trends in Cardiovascular Medicine·Glen W YoungPeipei Ping
May 16, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Krista L MoulderSteven Mennerick
Sep 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pascal S KaeserThomas C Südhof

❮ Previous
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Citations

May 18, 2012·Journal of Neural Transmission·Natasha BajicPaul T Francis
Jun 23, 2010·Learning & Memory·Ashok N Hegde
Jan 1, 2013·Molecular and Cellular Biology·Jiun-Tsai LinYijuang Chern
Jul 30, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chun Yun ChangSteven Mennerick
Jan 21, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Devon C CrawfordSteven Mennerick
Sep 13, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Devon C Crawford, Steven Mennerick
Apr 12, 2012·The Journal of Cell Biology·Arthur P H de JongMatthijs Verhage
May 29, 2013·The Journal of Cell Biology·Rubén Fernández-BusnadiegoVladan Lucić
May 25, 2011·Neurobiology of Disease·Joshua HoginsSteven Mennerick
Nov 17, 2010·Brain Research Bulletin·Diasynou Fioravante, John H Byrne
Nov 10, 2012·Journal of Integrative Plant Biology·Miaomiao Tian, Qi Xie
Nov 26, 2014·Journal of Neuroscience Research·Elena CaminosJose M Juiz
Oct 4, 2015·Trends in Molecular Medicine·Ewout J N Groen, Thomas H Gillingwater
Feb 28, 2015·Experimental Cell Research·Katrin MichelSusanne Schoch
Oct 28, 2011·Current Opinion in Neurobiology·Eckart D Gundelfinger, Anna Fejtova
May 21, 2011·Trends in Neurosciences·Clarissa L Waites, Craig C Garner
Oct 26, 2013·Progress in Neurobiology·Margarida V CaldeiraCarlos B Duarte
Feb 3, 2015·ELife·Beyenech BinottiReinhard Jahn
Nov 12, 2014·Annual Review of Physiology·Graeme W Davis, Martin Müller
Apr 27, 2017·Journal of Neurochemistry·Beatris AlonsoJosé Sánchez-Prieto
Apr 12, 2017·Neurochemical Research·James P ReynoldsDavid C Henshall
Jul 14, 2017·PLoS Computational Biology·Aseel ShomarNaama Brenner
May 19, 2012·Nature Reviews. Neuroscience·Bradley T Hyman, Junying Yuan
Oct 18, 2012·Physiological Reviews·Haruo KasaiHiroshi Tokumaru
Jul 15, 2015·EMBO Reports·Frauke AckermannCraig C Garner
Nov 1, 2016·The EMBO Journal·Vicky HakimNoam E Ziv
Sep 27, 2019·Synapse·C Andrew FrankMartin Müller
May 5, 2020·ELife·Sheila Hoffmann-ConawayCarolina Montenegro-Venegas
May 30, 2017·PloS One·Nguyen-Vi MohamedNicole Leclerc
Mar 26, 2011·Pharmacological Reviews·Irmgard TegederGerd Geisslinger
Jan 9, 2019·Frontiers in Cellular Neuroscience·Valentina LatinaGiuseppina Amadoro
Dec 23, 2017·The Journal of Biological Chemistry·Johnny J SaldateEdward L Stuenkel
Jun 6, 2018·International Journal of Molecular Sciences·Yong YangChaozhi Ma
Jan 29, 2020·CNS & Neurological Disorders Drug Targets·Carmen RubioCarlos Paz
Sep 10, 2020·International Journal of Molecular Sciences·Sara BachillerRocío Ruiz
Jun 18, 2017·F1000Research·Laurie D Cohen, Noam E Ziv

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