A Role for Tubular Necroptosis in Cisplatin-Induced AKI

Journal of the American Society of Nephrology : JASN
Yanfang XuJiahuai Han

Abstract

Cell death and inflammation in the proximal tubules are the hallmarks of cisplatin-induced AKI, but the mechanisms underlying these effects have not been fully elucidated. Here, we investigated whether necroptosis, a type of programmed necrosis, has a role in cisplatin-induced AKI. We found that inhibition of any of the core components of the necroptotic pathway-receptor-interacting protein 1 (RIP1), RIP3, or mixed lineage kinase domain-like protein (MLKL)-by gene knockout or a chemical inhibitor diminished cisplatin-induced proximal tubule damage in mice. Similar results were obtained in cultured proximal tubular cells. Furthermore, necroptosis of cultured cells could be induced by cisplatin or by a combination of cytokines (TNF-α, TNF-related weak inducer of apoptosis, and IFN-γ) that were upregulated in proximal tubules of cisplatin-treated mice. However, cisplatin induced an increase in RIP1 and RIP3 expression in cultured tubular cells in the absence of cytokine release. Correspondingly, overexpression of RIP1 or RIP3 enhanced cisplatin-induced necroptosis in vitro. Notably, inflammatory cytokine upregulation in cisplatin-treated mice was partially diminished in RIP3- or MLKL-deficient mice, suggesting a positive feedback ...Continue Reading

References

Oct 10, 1997·Nucleic Acids Research·C Li, R M Evans
Jun 18, 2002·The Journal of Pharmacology and Experimental Therapeutics·Brian S Cummings, Rick G Schnellmann
Jul 17, 2003·American Journal of Physiology. Renal Physiology·Ganesan Ramesh, W Brian Reeves
Sep 19, 2003·Seminars in Nephrology·Istvan Arany, Robert L Safirstein
Sep 28, 2006·Kidney International·P JustoA Ortiz
Oct 13, 2006·American Journal of Physiology. Renal Physiology·Ganesan RameshW Brian Reeves
Apr 6, 2007·Kidney International·Q WeiZ Dong
Nov 28, 2007·Annual Review of Pathology·Kenneth L Rock, Hajime Kono
Nov 18, 2011·Nature Immunology·Jiahuai HanDuan-Wu Zhang
Mar 23, 2012·Kidney International·Jinu KimBabu J Padanilam
Sep 4, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andreas LinkermannStefan Krautwald
Dec 12, 2012·Cancer Chemotherapy and Pharmacology·Kosuke OkadaToru Yanagawa
Jun 8, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anup RamachandranHartmut Jaeschke
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andreas LinkermannStefan Krautwald
Jul 10, 2013·Cell Research·Jianfeng WuJiahuai Han

❮ Previous
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Citations

Mar 1, 2016·Kidney International·Gur P Kaushal, Sudhir V Shah
Jan 14, 2016·Kidney International·Andreas Linkermann
Mar 5, 2016·Cell Death & Disease·S WangC Yang
Nov 8, 2015·Toxicology Letters·Abdullah OzkokCharles L Edelstein
Apr 8, 2016·Cellular and Molecular Life Sciences : CMLS·Tom Vanden BerghePeter Vandenabeele
Apr 18, 2016·Seminars in Nephrology·Shrikant R MulayHans-Joachim Anders
Jun 30, 2016·Journal of the American Society of Nephrology : JASN·Diego Martin-SanchezAna B Sanz
Jan 9, 2016·Journal of the American Society of Nephrology : JASN·Jiandong ZhangSteven D Crowley
Jan 10, 2017·Cellular Signalling·Yanfang XuRui-Qing Chen
Feb 1, 2018·Proceedings of the National Academy of Sciences of the United States of America·Wenjing LiuYin Xia
Jun 1, 2018·Nephron·Hans-Joachim Anders
Jun 21, 2018·American Journal of Physiology. Renal Physiology·Xueqiao WangAndong Qiu
Jan 10, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Takamasa IwakuraHans Joachim Anders
Feb 5, 2019·The Journal of Pathology·Wulf TonnusAndreas Linkermann
Oct 27, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ling JiangXiao-Ming Meng
Jun 22, 2018·Journal of the American Society of Nephrology : JASN·Bing YangMarie-Josée Hébert
Sep 4, 2015·Journal of the American Society of Nephrology : JASN·Shrikant R MulayHans-Joachim Anders
Apr 18, 2019·American Journal of Physiology. Renal Physiology·Wei CaoChangying Xing
Nov 20, 2015·Cell Death & Disease·H ZhaoD Ma
Nov 7, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xiao-Ming MengJun Li
Apr 28, 2017·American Journal of Physiology. Renal Physiology·Naijun MiaoLimin Lu
Oct 3, 2019·Journal of the American Society of Nephrology : JASN·Takuto ChibaSunder Sims-Lucas
Nov 2, 2019·Bioscience Reports·Demeng XiaShuogui Xu
Apr 3, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yu Jin JungWon Kim
May 10, 2020·JAMA Network Open·Kelly R McMahonUNKNOWN Applying Biomarkers to Minimize Long-term Effects of Childhood/Adolescent Cancer Treatment (ABLE) Research Study Group
Sep 12, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Qing-Song LinDe-Zhi Kang
Dec 14, 2016·Annual Review of Pathology·Lorenzo GalluzziGuido Kroemer
Jun 4, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Filiz MercantepeLevent Tumkaya
Oct 28, 2019·International Journal of Molecular Sciences·Daniela Maria TanaseCiprian Rezus
Jul 10, 2020·Journal of the American Society of Nephrology : JASN·Huihui HuangHua A Jenny Lu
Jul 8, 2020·International Journal of Molecular Sciences·Laura Martinez ValenzuelaJuan Torras

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