A role for xanthine oxidase in the control of fetal cardiovascular function in late gestation sheep.

The Journal of Physiology
Emilio A HerreraD A Giussani

Abstract

Virtually nothing is known about the effects on fetal physiology of xanthine oxidase inhibition. This is despite maternal treatment with the xanthine oxidase inhibitor allopurinol being considered in human complicated pregnancy to protect the infant’s brain from excessive generation of ROS.We investigated the in vivo effects of maternal treatment with allopurinol on fetal cardiovascular function in ovine pregnancy in late gestation. Under anaesthesia, pregnant ewes and their singleton fetus were instrumented with vascular catheters and flow probes around an umbilical and a fetal femoral artery at 118±1 dGA (days of gestational age; termca. 145 days). Five days later, mothers were infused I.V. with either vehicle (n =11) or allopurinol (n =10). Fetal cardiovascular function was stimulated with increasing bolus doses of phenylephrine (PE) following maternal vehicle or allopurinol. The effects of maternal allopurinol on maternal and fetal cardiovascular function were also investigated following fetal NO blockade (n =6) or fetal β1-adrenergic antagonism (n =7). Maternal allopurinol led to significant increases in fetal heart rate, umbilical blood flow and umbilical vascular conductance, effects abolished by fetal β1-adrenergic anta...Continue Reading

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Citations

Aug 1, 2012·Journal of Pregnancy·Loren P Thompson, Yazan Al-Hasan
Nov 20, 2013·The Journal of Physiology·Andrew D KaneDino A Giussani
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Mar 5, 2018·International Journal for Parasitology. Drugs and Drug Resistance·Roberto Sánchez-SánchezLuis Miguel Ortega-Mora

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